PRMT3 [The Human Chemical-Genetic Interaction Map Project]

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======= PRMT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT3
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10196|10196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60678|O60678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRMT5|
|Methyltransf 9|
|PrmA|
|MTS|
|Methyltransf 18|
|Methyltransf 11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-arginine omega-N asymmetric methyltransferase activity|
|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|
|protein-arginine N-methyltransferase activity|
|histone-arginine N-methyltransferase activity|
|peptidyl-arginine omega-N-methylation|
|peptidyl-arginine N-methylation|
|histone arginine methylation|
|peptidyl-arginine methylation|
|peptidyl-arginine modification|
|methyltransferase activity|
|ribosome binding|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|histone methylation|
|protein alkylation|
|protein methylation|
|nucleic acid binding|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|macromolecule methylation|
|methylation|
|histone modification|
|covalent chromatin modification|
|negative regulation of protein modification process|
|chromatin organization|
|peptidyl-amino acid modification|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.93|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.8|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.74|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.7|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.74|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.83|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.89|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.09|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18940
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT3 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>