PRMT7 [The Human Chemical-Genetic Interaction Map Project]

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======= PRMT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT7
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54496|54496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVM4|Q9NVM4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610087|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|[myelin basic protein]-arginine N-methyltransferase activity|
|histone methyltransferase activity (H4-R3 specific)|
|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|
|protein-arginine omega-N symmetric methyltransferase activity|
|protein-arginine omega-N monomethyltransferase activity|
|histone H4-R3 methylation|
|protein-arginine omega-N asymmetric methyltransferase activity|
|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|
|histone-arginine N-methyltransferase activity|
|peptidyl-arginine omega-N-methylation|
|S-adenosylmethionine-dependent methyltransferase activity|
|peptidyl-arginine N-methylation|
|histone arginine methylation|
|peptidyl-arginine methylation|
|regulation of gene expression by genetic imprinting|
|DNA methylation involved in gamete generation|
|genetic imprinting|
|peptidyl-arginine modification|
|ribonucleoprotein complex binding|
|spliceosomal snRNP assembly|
|DNA alkylation|
|DNA methylation|
|DNA methylation or demethylation|
|DNA modification|
|histone methylation|
|histone binding|
|fibrillar center|
|protein alkylation|
|protein methylation|
|regulation of protein binding|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|methylation|
|cellular process involved in reproduction in multicellular organism|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|gamete generation|
|mRNA metabolic process|
|chromatin organization|
|DNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|RNA processing|
|peptidyl-amino acid modification|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.85|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.56|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.45|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.43|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.27|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.14|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.03|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.95|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.9|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.86|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.78|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.73|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.71|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nob1|NOB1]]|0.422|
|[[:human genes:p:pds5b|PDS5B]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT7 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>