PROS1 [The Human Chemical-Genetic Interaction Map Project]

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======= PROS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PROS1
  * **<color #00a2e8>Official Name</color>**: protein S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5627|5627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07225|P07225]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PROS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PROS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gla|
|Laminin G 2|
|cEGF|
|Laminin G 1|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibrinolysis|
|endopeptidase inhibitor activity|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|platelet alpha granule lumen|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|Golgi lumen|
|regulation of complement activation|
|platelet degranulation|
|regulation of humoral immune response|
|regulation of wound healing|
|blood microparticle|
|regulation of response to wounding|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|Golgi vesicle transport|
|leukocyte migration|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|Golgi membrane|
|regulated exocytosis|
|calcium ion binding|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|exocytosis|
|endoplasmic reticulum membrane|
|cell migration|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|locomotion|
|regulation of response to stress|
|intracellular transport|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.98|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.86|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PROS1 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>