PRR7 [The Human Chemical-Genetic Interaction Map Project]

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======= PRR7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRR7
  * **<color #00a2e8>Official Name</color>**: proline rich 7, synaptic
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80758|80758]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TB68|Q8TB68]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRR7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRR7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|long-chain fatty acid binding|
|postsynapse to nucleus signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|postsynaptic density, intracellular component|
|ubiquitin-like protein ligase binding|
|protein tyrosine kinase binding|
|postsynaptic signal transduction|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|T cell differentiation|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of peptidase activity|
|postsynaptic membrane|
|regulation of protein ubiquitination|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein modification by small protein conjugation or removal|
|T cell activation|
|lymphocyte differentiation|
|regulation of cysteine-type endopeptidase activity|
|protein-containing complex binding|
|leukocyte differentiation|
|glutamatergic synapse|
|positive regulation of proteolysis|
|lymphocyte activation|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|dendrite|
|regulation of peptidase activity|
|synaptic signaling|
|cell junction|
|hemopoiesis|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|leukocyte activation|
|negative regulation of cellular protein metabolic process|
|cell activation|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.85|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.76|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.77|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.12|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRR7 Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>