PRRC2A [The Human Chemical-Genetic Interaction Map Project]

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======= PRRC2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRRC2A
  * **<color #00a2e8>Official Name</color>**: proline rich coiled-coil 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7916|7916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48634|P48634]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRRC2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRRC2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAT2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.16|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.08|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.83|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.89|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.07|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.23|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.69|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.28|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 55/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|3/26|
|breast|7/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|0/21|
|liver|4/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5391
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRRC2A Expression in NALM6 Cells: 9.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>