PRUNE [The Human Chemical-Genetic Interaction Map Project]

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======= PRUNE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRUNE1
  * **<color #00a2e8>Official Name</color>**: prune exopolyphosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58497|58497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86TP1|Q86TP1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRUNE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRUNE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617413|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DHH|
|DHHA2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inorganic diphosphatase activity|
|exopolyphosphatase activity|
|polyphosphate catabolic process|
|polyphosphate metabolic process|
|phosphatase activity|
|regulation of microtubule polymerization|
|tubulin binding|
|regulation of microtubule polymerization or depolymerization|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|dephosphorylation|
|regulation of supramolecular fiber organization|
|focal adhesion|
|regulation of protein complex assembly|
|regulation of cytoskeleton organization|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.31|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.1|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.01|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.98|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.95|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.88|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.79|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.75|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.13|
|[[:results:exp211|AICAR 240μM R05 exp211]]|4.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nudt2|NUDT2]]|0.486|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRUNE Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>