PSCA [The Human Chemical-Genetic Interaction Map Project]

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======= PSCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSCA
  * **<color #00a2e8>Official Name</color>**: prostate stem cell antigen
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8000|8000]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43653|O43653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269|PubMed:18488030}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPAR LY6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetylcholine receptor binding|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of neurotransmitter receptor activity|
|anchored component of membrane|
|negative regulation of MAPK cascade|
|regulation of signaling receptor activity|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of MAPK cascade|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14296
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSCA Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>