PSIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PSIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSIP1
  * **<color #00a2e8>Official Name</color>**: PC4 and SFRS1 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11168|11168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75475|O75475]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWWP|
|LEDGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|supercoiled DNA binding|
|mRNA 5-splice site recognition|
|establishment of integrated proviral latency|
|establishment of viral latency|
|viral latency|
|transcriptionally active chromatin|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|spliceosomal complex assembly|
|response to heat|
|response to temperature stimulus|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|response to oxidative stress|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA processing|
|response to abiotic stimulus|
|RNA binding|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.17|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.08|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.99|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.87|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.81|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.73|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSIP1 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>