PSMD2 [The Human Chemical-Genetic Interaction Map Project]

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======= PSMD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMD2
  * **<color #00a2e8>Official Name</color>**: proteasome 26S subunit, non-ATPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5708|5708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13200|Q13200]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606223|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PC rep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome storage granule|
|proteasome regulatory particle|
|proteasome regulatory particle, base subcomplex|
|enzyme regulator activity|
|proteasome accessory complex|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endopeptidase activity|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|secretory granule lumen|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|ficolin-1-rich granule lumen|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|positive regulation of Wnt signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|activation of innate immune response|
|regulation of animal organ morphogenesis|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|MAPK cascade|
|response to oxygen levels|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|activation of immune response|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulated exocytosis|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|exocytosis|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|leukocyte activation|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.95|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.88|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.31|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.02|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.92|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.82|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.79|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.75|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.7|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.92|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.99|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccna2|CCNA2]]|0.55|
|[[:human genes:p:psma6|PSMA6]]|0.549|
|[[:human genes:p:psma7|PSMA7]]|0.535|
|[[:human genes:r:rrp7a|RRP7A]]|0.523|
|[[:human genes:u:upf1|UPF1]]|0.521|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.521|
|[[:human genes:r:rpl35|RPL35]]|0.52|
|[[:human genes:c:chd4|CHD4]]|0.519|
|[[:human genes:p:psmb4|PSMB4]]|0.515|
|[[:human genes:p:polr2d|POLR2D]]|0.512|
|[[:human genes:p:pole|POLE]]|0.508|
|[[:human genes:p:psmb2|PSMB2]]|0.505|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.504|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.504|
|[[:human genes:s:ssh2|SSH2]]|0.502|
|[[:human genes:z:zfand5|ZFAND5]]|0.501|
|[[:human genes:l:lrr1|LRR1]]|0.497|
|[[:human genes:d:ddtl|DDTL]]|0.496|
|[[:human genes:d:dtl|DTL]]|0.496|
|[[:human genes:p:psmd1|PSMD1]]|0.491|
|[[:human genes:t:twistnb|TWISTNB]]|0.49|
|[[:human genes:p:psmd6|PSMD6]]|0.487|
|[[:human genes:d:ddx56|DDX56]]|0.484|
|[[:human genes:p:psmb1|PSMB1]]|0.483|
|[[:human genes:s:slc6a17|SLC6A17]]|0.483|
|[[:human genes:p:psmd14|PSMD14]]|0.478|
|[[:human genes:r:rps9|RPS9]]|0.475|
|[[:human genes:s:s1pr4|S1PR4]]|0.472|
|[[:human genes:n:npipb5|NPIPB5]]|0.47|
|[[:human genes:p:polr2j3|POLR2J3]]|0.469|
|[[:human genes:r:rps2|RPS2]]|0.469|
|[[:human genes:p:polr2f|POLR2F]]|0.468|
|[[:human genes:b:bysl|BYSL]]|0.467|
|[[:human genes:g:golga8j|GOLGA8J]]|0.462|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.461|
|[[:human genes:m:mt1e|MT1E]]|0.46|
|[[:human genes:c:c14orf93|C14orf93]]|0.46|
|[[:human genes:p:psmd3|PSMD3]]|0.46|
|[[:human genes:r:rrp15|RRP15]]|0.459|
|[[:human genes:r:rad51|RAD51]]|0.458|
|[[:human genes:s:stil|STIL]]|0.457|
|[[:human genes:e:exosc5|EXOSC5]]|0.457|
|[[:human genes:c:ctage4|CTAGE4]]|0.457|
|[[:human genes:t:tspy1|TSPY1]]|0.455|
|[[:human genes:n:nup160|NUP160]]|0.455|
|[[:human genes:m:mcoln1|MCOLN1]]|0.454|
|[[:human genes:l:lad1|LAD1]]|0.454|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.454|
|[[:human genes:r:rps12|RPS12]]|0.453|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.453|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.451|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.45|
|[[:human genes:a:art5|ART5]]|0.448|
|[[:human genes:u:utp3|UTP3]]|0.447|
|[[:human genes:p:psmc2|PSMC2]]|0.447|
|[[:human genes:s:snrpa1|SNRPA1]]|0.443|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.442|
|[[:human genes:r:rps7|RPS7]]|0.441|
|[[:human genes:a:ahctf1|AHCTF1]]|0.44|
|[[:human genes:c:cdc73|CDC73]]|0.44|
|[[:human genes:c:copg1|COPG1]]|0.44|
|[[:human genes:k:kctd17|KCTD17]]|0.439|
|[[:human genes:p:psmc1|PSMC1]]|0.439|
|[[:human genes:t:tceb3c|TCEB3C]]|0.438|
|[[:human genes:c:cbwd3|CBWD3]]|0.438|
|[[:human genes:p:pwp2|PWP2]]|0.437|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.434|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.433|
|[[:human genes:a:atp13a1|ATP13A1]]|0.433|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.433|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.433|
|[[:human genes:p:psmd11|PSMD11]]|0.432|
|[[:human genes:p:pop7|POP7]]|0.43|
|[[:human genes:m:myh7b|MYH7B]]|0.43|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.429|
|[[:human genes:v:vasn|VASN]]|0.426|
|[[:human genes:r:rnpc3|RNPC3]]|0.426|
|[[:human genes:n:narfl|NARFL]]|0.426|
|[[:human genes:p:psmb3|PSMB3]]|0.425|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.425|
|[[:human genes:c:cbwd5|CBWD5]]|0.425|
|[[:human genes:g:golga8o|GOLGA8O]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.424|
|[[:human genes:s:slc38a7|SLC38A7]]|0.424|
|[[:human genes:i:ints5|INTS5]]|0.423|
|[[:human genes:r:rrn3|RRN3]]|0.423|
|[[:human genes:k:krt2|KRT2]]|0.423|
|[[:human genes:k:krt78|KRT78]]|0.422|
|[[:human genes:a:aamp|AAMP]]|0.422|
|[[:human genes:z:znf830|ZNF830]]|0.422|
|[[:human genes:t:tsg101|TSG101]]|0.421|
|[[:human genes:r:rpl6|RPL6]]|0.421|
|[[:human genes:h:hap1|HAP1]]|0.421|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:n:nelfcd|NELFCD]]|0.42|
|[[:human genes:o:orc6|ORC6]]|0.42|
|[[:human genes:s:slc4a1|SLC4A1]]|0.419|
|[[:human genes:s:sult1a3|SULT1A3]]|0.418|
|[[:human genes:s:sult1a4|SULT1A4]]|0.418|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.418|
|[[:human genes:c:col2a1|COL2A1]]|0.418|
|[[:human genes:p:pan3|PAN3]]|0.418|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.418|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:e:exosc4|EXOSC4]]|0.417|
|[[:human genes:c:cactin|CACTIN]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:e:exosc9|EXOSC9]]|0.416|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.416|
|[[:human genes:r:riok2|RIOK2]]|0.416|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.416|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.416|
|[[:human genes:p:psma1|PSMA1]]|0.415|
|[[:human genes:n:nup133|NUP133]]|0.415|
|[[:human genes:n:nol10|NOL10]]|0.415|
|[[:human genes:f:fam86b2|FAM86B2]]|0.413|
|[[:human genes:t:tspy2|TSPY2]]|0.413|
|[[:human genes:s:sap30bp|SAP30BP]]|0.413|
|[[:human genes:g:golga8k|GOLGA8K]]|0.413|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.412|
|[[:human genes:g:golga8h|GOLGA8H]]|0.412|
|[[:human genes:c:cope|COPE]]|0.411|
|[[:human genes:e:eif4a3|EIF4A3]]|0.411|
|[[:human genes:r:rps3|RPS3]]|0.411|
|[[:human genes:p:polr2i|POLR2I]]|0.411|
|[[:human genes:a:aqr|AQR]]|0.411|
|[[:human genes:p:pbxip1|PBXIP1]]|0.409|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.409|
|[[:human genes:d:ddx21|DDX21]]|0.409|
|[[:human genes:s:sec13|SEC13]]|0.408|
|[[:human genes:c:cdca3|CDCA3]]|0.408|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.407|
|[[:human genes:e:esf1|ESF1]]|0.407|
|[[:human genes:r:rpsa|RPSA]]|0.407|
|[[:human genes:p:psmc6|PSMC6]]|0.406|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.405|
|[[:human genes:r:rad21|RAD21]]|0.405|
|[[:human genes:c:cgb2|CGB2]]|0.405|
|[[:human genes:t:tyms|TYMS]]|0.405|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.404|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.404|
|[[:human genes:n:nup54|NUP54]]|0.403|
|[[:human genes:p:pola1|POLA1]]|0.403|
|[[:human genes:c:ccdc116|CCDC116]]|0.402|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.401|
|[[:human genes:c:cdh24|CDH24]]|0.4|
|[[:human genes:b:bage3|BAGE3]]|0.4|
|[[:human genes:p:psmc4|PSMC4]]|0.4|
|[[:human genes:b:bage2|BAGE2]]|0.4|
|[[:human genes:d:ddt|DDT]]|0.4|
|[[:human genes:r:rfc1|RFC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 503/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|24/28|
|bone|17/26|
|breast|22/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|13/21|
|liver|17/20|
|lung|43/75|
|lymphocyte|13/16|
|ovary|20/26|
|pancreas|16/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|19/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 817
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMD2 Expression in NALM6 Cells: 8.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>