PSMG2 [The Human Chemical-Genetic Interaction Map Project]

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======= PSMG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMG2
  * **<color #00a2e8>Official Name</color>**: proteasome assembly chaperone 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56984|56984]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969U7|Q969U7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609702|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAC2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome assembly|
|spindle checkpoint|
|mitotic spindle checkpoint|
|mitotic spindle assembly checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|negative regulation of chromosome organization|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|cellular protein-containing complex assembly|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.76|
|[[:results:exp302|35°C R06 exp302]]|1.77|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.83|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.86|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.02|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.02|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.1|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmg1|PSMG1]]|0.443|
|[[:human genes:p:psmg4|PSMG4]]|0.431|
|[[:human genes:d:dolk|DOLK]]|0.427|
|[[:human genes:r:rabggtb|RABGGTB]]|0.424|
|[[:human genes:d:dhrsx|DHRSX]]|0.41|
|[[:human genes:p:pgm3|PGM3]]|0.402|
|[[:human genes:p:ppcdc|PPCDC]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 270/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|11/28|
|bone|10/26|
|breast|16/33|
|central nervous system|17/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|7/20|
|lung|18/75|
|lymphocyte|7/16|
|ovary|11/26|
|pancreas|20/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1066
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMG2 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>