PTAR1 [The Human Chemical-Genetic Interaction Map Project]

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======= PTAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTAR1
  * **<color #00a2e8>Official Name</color>**: protein prenyltransferase alpha subunit repeat containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375743|375743]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6K3|Q7Z6K3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621024|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PPTA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein prenyltransferase activity|
|prenylation|
|protein prenylation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.93|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.52|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.48|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.27|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.22|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.17|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.09|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.87|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.82|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.81|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.79|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.76|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.75|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.73|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.72|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.73|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.75|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.79|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.82|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.92|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.07|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.08|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.11|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.22|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.29|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.46|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.77|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.98|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|3.34|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wrb|WRB]]|0.579|
|[[:human genes:p:ppp6c|PPP6C]]|0.548|
|[[:human genes:r:rabggtb|RABGGTB]]|0.543|
|[[:human genes:g:get4|GET4]]|0.542|
|[[:human genes:p:pmvk|PMVK]]|0.53|
|[[:human genes:c:c15orf41|C15orf41]]|0.517|
|[[:human genes:g:gemin6|GEMIN6]]|0.504|
|[[:human genes:p:ppcdc|PPCDC]]|0.503|
|[[:human genes:d:dhrsx|DHRSX]]|0.495|
|[[:human genes:t:trmt61a|TRMT61A]]|0.491|
|[[:human genes:c:cxorf56|CXorf56]]|0.489|
|[[:human genes:p:pgm3|PGM3]]|0.483|
|[[:human genes:w:wdr83|WDR83]]|0.475|
|[[:human genes:t:ten1|TEN1]]|0.47|
|[[:human genes:g:gemin8|GEMIN8]]|0.46|
|[[:human genes:t:tube1|TUBE1]]|0.458|
|[[:human genes:f:fen1|FEN1]]|0.449|
|[[:human genes:r:rpp21|RPP21]]|0.444|
|[[:human genes:r:rpia|RPIA]]|0.444|
|[[:human genes:m:mettl14|METTL14]]|0.441|
|[[:human genes:g:gemin7|GEMIN7]]|0.439|
|[[:human genes:f:fh|FH]]|0.439|
|[[:human genes:t:tubd1|TUBD1]]|0.434|
|[[:human genes:r:rft1|RFT1]]|0.433|
|[[:human genes:p:ppcs|PPCS]]|0.433|
|[[:human genes:d:dr1|DR1]]|0.423|
|[[:human genes:m:msto1|MSTO1]]|0.422|
|[[:human genes:t:thg1l|THG1L]]|0.417|
|[[:human genes:d:dph1|DPH1]]|0.415|
|[[:human genes:s:srp14|SRP14]]|0.415|
|[[:human genes:e:elp6|ELP6]]|0.414|
|[[:human genes:e:elp3|ELP3]]|0.411|
|[[:human genes:g:gemin4|GEMIN4]]|0.409|
|[[:human genes:s:sepsecs|SEPSECS]]|0.409|
|[[:human genes:n:n6amt1|N6AMT1]]|0.405|
|[[:human genes:l:lsm10|LSM10]]|0.403|
|[[:human genes:d:dnlz|DNLZ]]|0.402|
|[[:human genes:d:ddx39a|DDX39A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 21/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1533
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTAR1 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>