PTCD3 [The Human Chemical-Genetic Interaction Map Project]

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======= PTCD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTCD3
  * **<color #00a2e8>Official Name</color>**: pentatricopeptide repeat domain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55037|55037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EY7|Q96EY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTCD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTCD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614918|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial RNA-binding protein that has a role in mitochondrial translation. {ECO:0000269|PubMed:19427859}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit binding|
|rRNA binding|
|ribosome|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|regulation of translation|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.85|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.95|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl45|MRPL45]]|0.554|
|[[:human genes:d:ddx28|DDX28]]|0.531|
|[[:human genes:p:pet117|PET117]]|0.531|
|[[:human genes:m:mrpl3|MRPL3]]|0.524|
|[[:human genes:c:coa3|COA3]]|0.522|
|[[:human genes:t:tfb1m|TFB1M]]|0.522|
|[[:human genes:t:trub2|TRUB2]]|0.522|
|[[:human genes:q:qrsl1|QRSL1]]|0.522|
|[[:human genes:m:mettl17|METTL17]]|0.514|
|[[:human genes:m:mrps16|MRPS16]]|0.511|
|[[:human genes:e:eral1|ERAL1]]|0.51|
|[[:human genes:m:mrps27|MRPS27]]|0.51|
|[[:human genes:f:ftsj2|FTSJ2]]|0.507|
|[[:human genes:m:mrp63|MRP63]]|0.499|
|[[:human genes:n:nars2|NARS2]]|0.497|
|[[:human genes:m:mrpl17|MRPL17]]|0.493|
|[[:human genes:p:polrmt|POLRMT]]|0.491|
|[[:human genes:m:mrps21|MRPS21]]|0.49|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.488|
|[[:human genes:n:ndufb11|NDUFB11]]|0.488|
|[[:human genes:m:mrps12|MRPS12]]|0.487|
|[[:human genes:d:dap3|DAP3]]|0.485|
|[[:human genes:m:mrps25|MRPS25]]|0.485|
|[[:human genes:r:rpusd3|RPUSD3]]|0.483|
|[[:human genes:a:acad9|ACAD9]]|0.482|
|[[:human genes:c:chchd1|CHCHD1]]|0.481|
|[[:human genes:f:fastkd2|FASTKD2]]|0.478|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.477|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.475|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.473|
|[[:human genes:n:ndufs2|NDUFS2]]|0.467|
|[[:human genes:m:mrpl33|MRPL33]]|0.466|
|[[:human genes:m:mrps6|MRPS6]]|0.466|
|[[:human genes:m:mrpl47|MRPL47]]|0.466|
|[[:human genes:m:mtpap|MTPAP]]|0.465|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.464|
|[[:human genes:m:malsu1|MALSU1]]|0.464|
|[[:human genes:m:mrps34|MRPS34]]|0.464|
|[[:human genes:c:cars2|CARS2]]|0.463|
|[[:human genes:m:mrpl42|MRPL42]]|0.462|
|[[:human genes:n:ndufa3|NDUFA3]]|0.462|
|[[:human genes:r:rars2|RARS2]]|0.461|
|[[:human genes:m:mrps22|MRPS22]]|0.459|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.458|
|[[:human genes:p:pet112|PET112]]|0.457|
|[[:human genes:m:mrpl13|MRPL13]]|0.455|
|[[:human genes:n:nubpl|NUBPL]]|0.455|
|[[:human genes:a:aifm1|AIFM1]]|0.454|
|[[:human genes:s:ssbp1|SSBP1]]|0.454|
|[[:human genes:m:mars2|MARS2]]|0.454|
|[[:human genes:w:wbscr16|WBSCR16]]|0.454|
|[[:human genes:n:ndufc2|NDUFC2]]|0.453|
|[[:human genes:m:mrpl23|MRPL23]]|0.453|
|[[:human genes:c:coa6|COA6]]|0.452|
|[[:human genes:m:mrpl22|MRPL22]]|0.452|
|[[:human genes:v:vars2|VARS2]]|0.45|
|[[:human genes:m:mrpl51|MRPL51]]|0.449|
|[[:human genes:m:mtif2|MTIF2]]|0.449|
|[[:human genes:t:tfam|TFAM]]|0.449|
|[[:human genes:m:mrps14|MRPS14]]|0.449|
|[[:human genes:p:pars2|PARS2]]|0.443|
|[[:human genes:m:mrpl15|MRPL15]]|0.443|
|[[:human genes:s:sco2|SCO2]]|0.441|
|[[:human genes:n:ndufa1|NDUFA1]]|0.44|
|[[:human genes:n:ndufb9|NDUFB9]]|0.439|
|[[:human genes:m:mrpl44|MRPL44]]|0.439|
|[[:human genes:y:yars2|YARS2]]|0.439|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.439|
|[[:human genes:s:selrc1|SELRC1]]|0.438|
|[[:human genes:l:lrpprc|LRPPRC]]|0.438|
|[[:human genes:m:mrps18b|MRPS18B]]|0.434|
|[[:human genes:m:mrps18a|MRPS18A]]|0.433|
|[[:human genes:m:mrpl11|MRPL11]]|0.432|
|[[:human genes:n:nsun4|NSUN4]]|0.431|
|[[:human genes:m:mterfd2|MTERFD2]]|0.43|
|[[:human genes:n:ndufc1|NDUFC1]]|0.429|
|[[:human genes:m:mrpl48|MRPL48]]|0.428|
|[[:human genes:r:rbfa|RBFA]]|0.428|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.427|
|[[:human genes:g:gfm1|GFM1]]|0.426|
|[[:human genes:l:lars2|LARS2]]|0.423|
|[[:human genes:t:tars2|TARS2]]|0.423|
|[[:human genes:m:mrps10|MRPS10]]|0.423|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.422|
|[[:human genes:m:mrpl37|MRPL37]]|0.422|
|[[:human genes:m:mrps26|MRPS26]]|0.422|
|[[:human genes:c:c1qbp|C1QBP]]|0.422|
|[[:human genes:m:mrps9|MRPS9]]|0.421|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.421|
|[[:human genes:w:wars2|WARS2]]|0.42|
|[[:human genes:f:fastkd5|FASTKD5]]|0.419|
|[[:human genes:m:mrps7|MRPS7]]|0.417|
|[[:human genes:e:ecsit|ECSIT]]|0.417|
|[[:human genes:m:mterfd1|MTERFD1]]|0.417|
|[[:human genes:t:tfb2m|TFB2M]]|0.417|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.416|
|[[:human genes:n:ndufv1|NDUFV1]]|0.415|
|[[:human genes:m:mrpl35|MRPL35]]|0.415|
|[[:human genes:m:mrpl41|MRPL41]]|0.414|
|[[:human genes:p:prepl|PREPL]]|0.414|
|[[:human genes:n:ndufb6|NDUFB6]]|0.414|
|[[:human genes:a:aars2|AARS2]]|0.414|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.414|
|[[:human genes:m:mrpl49|MRPL49]]|0.412|
|[[:human genes:m:mtg2|MTG2]]|0.412|
|[[:human genes:g:grsf1|GRSF1]]|0.412|
|[[:human genes:s:slc31a1|SLC31A1]]|0.411|
|[[:human genes:n:ndufb10|NDUFB10]]|0.41|
|[[:human genes:e:ears2|EARS2]]|0.409|
|[[:human genes:m:mrpl21|MRPL21]]|0.409|
|[[:human genes:d:dars2|DARS2]]|0.409|
|[[:human genes:n:ndufb4|NDUFB4]]|0.408|
|[[:human genes:n:ndufa2|NDUFA2]]|0.408|
|[[:human genes:m:mcat|MCAT]]|0.407|
|[[:human genes:c:cox6b1|COX6B1]]|0.406|
|[[:human genes:m:mrpl43|MRPL43]]|0.406|
|[[:human genes:c:cox6a1|COX6A1]]|0.406|
|[[:human genes:r:rmnd1|RMND1]]|0.403|
|[[:human genes:m:mrpl39|MRPL39]]|0.403|
|[[:human genes:n:ndufs3|NDUFS3]]|0.402|
|[[:human genes:m:mrpl53|MRPL53]]|0.402|
|[[:human genes:c:c12orf65|C12orf65]]|0.401|
|[[:human genes:c:clpp|CLPP]]|0.401|
|[[:human genes:c:cox18|COX18]]|0.401|
|[[:human genes:c:coq2|COQ2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 183/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|6/28|
|bone|6/26|
|breast|11/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|4/21|
|liver|7/20|
|lung|23/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|5/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 584
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTCD3 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>