PTGDR [The Human Chemical-Genetic Interaction Map Project]

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======= PTGDR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGDR
  * **<color #00a2e8>Official Name</color>**: prostaglandin D2 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5729|5729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13258|Q13258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGDR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGDR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604687|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin D receptor activity|
|prostaglandin J receptor activity|
|cellular response to prostaglandin D stimulus|
|response to prostaglandin D|
|adenosine metabolic process|
|sleep|
|male sex determination|
|cellular response to prostaglandin stimulus|
|sex determination|
|response to prostaglandin|
|cellular response to fatty acid|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside metabolic process|
|cellular response to alcohol|
|response to fatty acid|
|cellular response to ketone|
|nucleoside metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|glycosyl compound metabolic process|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|response to ketone|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to acid chemical|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|response to acid chemical|
|purine-containing compound metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|drug metabolic process|
|cellular response to lipid|
|nucleobase-containing small molecule metabolic process|
|cellular metal ion homeostasis|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|developmental process involved in reproduction|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|defense response|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.516|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9820
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGDR Expression in NALM6 Cells: 3.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>