PTGER4 [The Human Chemical-Genetic Interaction Map Project]

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======= PTGER4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGER4
  * **<color #00a2e8>Official Name</color>**: prostaglandin E receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5734|5734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35408|P35408]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGER4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGER4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601586|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of eosinophil extravasation|
|negative regulation of eosinophil extravasation|
|negative regulation of eosinophil migration|
|negative regulation of integrin activation|
|regulation of eosinophil migration|
|prostaglandin E receptor activity|
|negative regulation of cellular extravasation|
|regulation of integrin activation|
|cellular response to prostaglandin E stimulus|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|ERK1 and ERK2 cascade|
|alpha-beta T cell activation involved in immune response|
|regulation of cellular extravasation|
|response to prostaglandin|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|negative regulation of leukocyte migration|
|alpha-beta T cell differentiation|
|cellular response to fatty acid|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|negative regulation of cytokine secretion|
|regulation of stress fiber assembly|
|cellular response to mechanical stimulus|
|JNK cascade|
|cellular response to alcohol|
|response to fatty acid|
|regulation of actomyosin structure organization|
|cellular response to ketone|
|regulation of actin filament bundle assembly|
|stress-activated MAPK cascade|
|lymphocyte activation involved in immune response|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of protein complex assembly|
|negative regulation of protein secretion|
|T cell differentiation|
|negative regulation of inflammatory response|
|positive regulation of inflammatory response|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|stress-activated protein kinase signaling cascade|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of ossification|
|response to ketone|
|regulation of leukocyte migration|
|bone development|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to acid chemical|
|response to mechanical stimulus|
|negative regulation of secretion|
|response to alcohol|
|T cell activation|
|lymphocyte differentiation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of cell migration|
|regulation of actin filament organization|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|cellular response to external stimulus|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|MAPK cascade|
|lymphocyte activation|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|skeletal system development|
|regulation of peptide secretion|
|inflammatory response|
|cellular response to lipid|
|regulation of cytoskeleton organization|
|cellular metal ion homeostasis|
|hemopoiesis|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|immune system development|
|response to bacterium|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|ion homeostasis|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|leukocyte activation|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3496
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGER4 Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>