PTMA [The Human Chemical-Genetic Interaction Map Project]

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======= PTMA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTMA
  * **<color #00a2e8>Official Name</color>**: prothymosin alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5757|5757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06454|P06454]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTMA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTMA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prothymosin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activating transcription factor binding|
|histone exchange|
|ATP-dependent chromatin remodeling|
|histone binding|
|nucleosome organization|
|chromatin remodeling|
|protein-DNA complex subunit organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.46|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.07|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.05|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.88|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.7|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.7|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.79|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.8|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.81|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.85|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.86|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.87|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.87|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.88|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.96|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.97|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.05|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.07|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.11|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.14|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.25|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.25|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.28|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.41|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.62|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.82|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.98|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.3|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3.31|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.41|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.98|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.14|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|4.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddx3x|DDX3X]]|0.516|
|[[:human genes:g:glyr1|GLYR1]]|0.433|
|[[:human genes:p:pmaip1|PMAIP1]]|0.43|
|[[:human genes:p:prim1|PRIM1]]|0.43|
|[[:human genes:i:ikzf2|IKZF2]]|0.419|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.414|
|[[:human genes:c:cnbp|CNBP]]|0.41|
|[[:human genes:a:anp32a|ANP32A]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTMA Expression in NALM6 Cells: 11.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>