PTP4A3 [The Human Chemical-Genetic Interaction Map Project]

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======= PTP4A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTP4A3
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase 4A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11156|11156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75365|O75365]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTP4A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTP4A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606449|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prenylated protein tyrosine phosphatase activity|
|positive regulation of vascular permeability|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|regulation of vascular permeability|
|protein tyrosine/serine/threonine phosphatase activity|
|endothelial cell migration|
|positive regulation of NIK/NF-kappaB signaling|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|regulation of NIK/NF-kappaB signaling|
|Notch signaling pathway|
|vascular process in circulatory system|
|ameboidal-type cell migration|
|protein dephosphorylation|
|early endosome|
|regulation of cellular response to growth factor stimulus|
|dephosphorylation|
|blood circulation|
|circulatory system process|
|positive regulation of establishment of protein localization|
|regulation of establishment of protein localization|
|cell migration|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cell motility|
|localization of cell|
|response to cytokine|
|locomotion|
|movement of cell or subcellular component|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTP4A3 Expression in NALM6 Cells: 1.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>