PTPN22 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN22
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26191|26191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2R2|Q9Y2R2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600716|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoanandamide dephosphorylation|
|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|
|negative regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|positive regulation of protein K63-linked ubiquitination|
|negative regulation of p38MAPK cascade|
|regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|
|positive regulation of toll-like receptor 3 signaling pathway|
|negative regulation of interleukin-8 secretion|
|positive regulation of interferon-gamma secretion|
|positive regulation of toll-like receptor 4 signaling pathway|
|cellular response to muramyl dipeptide|
|regulation of natural killer cell proliferation|
|regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|regulation of toll-like receptor 3 signaling pathway|
|regulation of protein K63-linked ubiquitination|
|negative regulation of interleukin-6 secretion|
|regulation of interferon-gamma secretion|
|positive regulation of protein polyubiquitination|
|negative regulation of JUN kinase activity|
|negative regulation of interleukin-8 production|
|negative regulation of T cell receptor signaling pathway|
|response to muramyl dipeptide|
|regulation of toll-like receptor 4 signaling pathway|
|regulation of protein polyubiquitination|
|positive regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 secretion|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of natural killer cell activation|
|lipopolysaccharide-mediated signaling pathway|
|negative regulation of JNK cascade|
|regulation of T cell receptor signaling pathway|
|regulation of p38MAPK cascade|
|negative regulation of interleukin-6 production|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|phosphatase activity|
|cytoplasmic side of plasma membrane|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of interferon-gamma production|
|regulation of toll-like receptor signaling pathway|
|negative regulation of cytokine secretion|
|regulation of interleukin-8 production|
|negative regulation of MAP kinase activity|
|positive regulation of type I interferon production|
|negative regulation of autophagy|
|regulation of JUN kinase activity|
|kinase binding|
|regulation of interferon-gamma production|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of T cell activation|
|positive regulation of protein ubiquitination|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of type I interferon production|
|SH3 domain binding|
|negative regulation of protein secretion|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of protein modification by small protein conjugation or removal|
|T cell differentiation|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|negative regulation of lymphocyte activation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of MAPK cascade|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|T cell receptor signaling pathway|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|regulation of protein ubiquitination|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|protein dephosphorylation|
|cellular response to biotic stimulus|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|negative regulation of kinase activity|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|dephosphorylation|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|cellular response to peptide|
|leukocyte differentiation|
|regulation of autophagy|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of MAPK cascade|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|leukocyte activation|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15952
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN22 Expression in NALM6 Cells: 2.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>