PTPN3 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN3
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5774|5774]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26045|P26045]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176877|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM N|
|FERM M|
|Y phosphatase|
|DSPc|
|PDZ|
|FERM C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of membrane depolarization during action potential|
|negative regulation of membrane protein ectodomain proteolysis|
|regulation of membrane protein ectodomain proteolysis|
|liver regeneration|
|sodium channel regulator activity|
|phosphotyrosine residue binding|
|regulation of membrane depolarization|
|negative regulation of epidermal growth factor receptor signaling pathway|
|regulation of action potential|
|negative regulation of ERBB signaling pathway|
|cytoplasmic side of plasma membrane|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|animal organ regeneration|
|cytoskeletal protein binding|
|ATPase binding|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of sodium ion transport|
|regulation of ERBB signaling pathway|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|liver development|
|hepaticobiliary system development|
|negative regulation of protein catabolic process|
|regeneration|
|protein dephosphorylation|
|negative regulation of cellular catabolic process|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|negative regulation of mitotic cell cycle|
|dephosphorylation|
|negative regulation of catabolic process|
|regulation of cation transmembrane transport|
|negative regulation of proteolysis|
|cytoskeleton|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|gland development|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of ion transport|
|regulation of proteolysis|
|ion homeostasis|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|regulation of cell cycle|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.9|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12744
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN3 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>