PTPN6 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN6
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5777|5777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29350|P29350]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|abortive mitotic cell cycle|
|phosphorylation-dependent protein binding|
|alpha-beta T cell receptor complex|
|negative regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of immunoglobulin mediated immune response|
|negative regulation of B cell mediated immunity|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of humoral immune response|
|transmembrane receptor protein tyrosine phosphatase activity|
|megakaryocyte development|
|platelet formation|
|negative regulation of T cell receptor signaling pathway|
|positive regulation of cell adhesion mediated by integrin|
|platelet morphogenesis|
|megakaryocyte differentiation|
|bone cell development|
|natural killer cell mediated cytotoxicity|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of B cell differentiation|
|natural killer cell mediated immunity|
|regulation of type I interferon-mediated signaling pathway|
|SH2 domain binding|
|negative regulation of lymphocyte mediated immunity|
|regulation of T cell receptor signaling pathway|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|phosphotyrosine residue binding|
|leukocyte mediated cytotoxicity|
|negative regulation of interleukin-6 production|
|platelet aggregation|
|negative regulation of adaptive immune response|
|regulation of cell adhesion mediated by integrin|
|negative regulation of leukocyte mediated immunity|
|regulation of immunoglobulin mediated immune response|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of B cell mediated immunity|
|T cell costimulation|
|lymphocyte costimulation|
|tertiary granule lumen|
|cell adhesion molecule binding|
|negative regulation of tumor necrosis factor production|
|myeloid cell development|
|homotypic cell-cell adhesion|
|negative regulation of T cell proliferation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|specific granule lumen|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of lymphocyte proliferation|
|negative regulation of MAP kinase activity|
|negative regulation of mononuclear cell proliferation|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of leukocyte proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|hematopoietic progenitor cell differentiation|
|cell killing|
|regulation of calcium ion transport into cytosol|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of T cell activation|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of sequestering of calcium ion|
|B cell receptor signaling pathway|
|SH3 domain binding|
|negative regulation of protein serine/threonine kinase activity|
|regulation of humoral immune response|
|platelet activation|
|regulation of interleukin-6 production|
|peptidyl-tyrosine phosphorylation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|peptidyl-tyrosine modification|
|regulation of calcium ion transmembrane transport|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|regulation of cell cycle G1/S phase transition|
|negative regulation of MAPK cascade|
|regulation of lymphocyte differentiation|
|cell-cell junction|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|negative regulation of cell activation|
|bone development|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|protein dephosphorylation|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|blood coagulation|
|antigen receptor-mediated signaling pathway|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|dephosphorylation|
|regulation of T cell activation|
|regulation of cation transmembrane transport|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|positive regulation of cell activation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|regulation of ion transmembrane transport|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|skeletal system development|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|response to wounding|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|cell morphogenesis|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|nucleolus|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|programmed cell death|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.71|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.21|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.18|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.15|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.05|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.86|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.84|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.07|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.12|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd5|KCTD5]]|0.423|
|[[:human genes:f:fcrla|FCRLA]]|0.408|
|[[:human genes:c:cd72|CD72]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10517
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN6 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>