PTPRC [The Human Chemical-Genetic Interaction Map Project]

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======= PTPRC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRC
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5788|5788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08575|P08575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:2845400}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTP N|
|CD45|
|Y phosphatase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane raft localization|
|plasma membrane raft distribution|
|DN2 thymocyte differentiation|
|positive regulation of hematopoietic stem cell migration|
|regulation of hematopoietic stem cell migration|
|immunoglobulin biosynthetic process|
|membrane microdomain|
|positive regulation of gamma-delta T cell differentiation|
|positive regulation of protein tyrosine phosphatase activity|
|negative regulation of cell adhesion involved in substrate-bound cell migration|
|membrane raft distribution|
|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|membrane raft localization|
|positive regulation of gamma-delta T cell activation|
|negative regulation of interleukin-2 biosynthetic process|
|regulation of gamma-delta T cell differentiation|
|positive regulation of humoral immune response mediated by circulating immunoglobulin|
|regulation of protein tyrosine phosphatase activity|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|negative regulation of T cell mediated cytotoxicity|
|negative regulation of microglial cell activation|
|regulation of gamma-delta T cell activation|
|positive regulation of Fc receptor mediated stimulatory signaling pathway|
|bone marrow development|
|natural killer cell differentiation|
|bleb|
|positive regulation of isotype switching to IgG isotypes|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|positive thymic T cell selection|
|negative thymic T cell selection|
|regulation of isotype switching to IgG isotypes|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of neuroinflammatory response|
|negative T cell selection|
|negative regulation of protein autophosphorylation|
|positive regulation of interleukin-2 biosynthetic process|
|negative regulation of macrophage activation|
|heparan sulfate proteoglycan binding|
|positive regulation of humoral immune response|
|transmembrane receptor protein tyrosine phosphatase activity|
|regulation of microglial cell activation|
|negative regulation of leukocyte mediated cytotoxicity|
|thymic T cell selection|
|negative regulation of T cell mediated immunity|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of alpha-beta T cell proliferation|
|ankyrin binding|
|positive regulation of phosphoprotein phosphatase activity|
|membrane raft organization|
|negative regulation of cell killing|
|positive regulation of antigen receptor-mediated signaling pathway|
|negative regulation of interleukin-2 production|
|calcium-mediated signaling using intracellular calcium source|
|positive regulation of isotype switching|
|positive regulation of T cell mediated cytotoxicity|
|positive T cell selection|
|substrate-dependent cell migration|
|spectrin binding|
|negative regulation of protein tyrosine kinase activity|
|regulation of alpha-beta T cell proliferation|
|positive regulation of interleukin-2 production|
|negative regulation of cytokine biosynthetic process|
|regulation of neuroinflammatory response|
|regulation of T cell mediated cytotoxicity|
|regulation of isotype switching|
|positive regulation of phosphatase activity|
|heterotypic cell-cell adhesion|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|negative regulation of lymphocyte mediated immunity|
|T cell proliferation|
|positive regulation of DNA recombination|
|T cell selection|
|positive regulation of stem cell proliferation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of B cell proliferation|
|B cell proliferation|
|positive regulation of immunoglobulin production|
|positive regulation of protein dephosphorylation|
|negative regulation of adaptive immune response|
|T cell differentiation in thymus|
|regulation of protein autophosphorylation|
|positive regulation of T cell mediated immunity|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of leukocyte mediated immunity|
|leukocyte cell-cell adhesion|
|regulation of immunoglobulin mediated immune response|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of B cell mediated immunity|
|regulation of macrophage activation|
|cytoplasmic side of plasma membrane|
|regulation of interleukin-2 production|
|release of sequestered calcium ion into cytosol|
|positive regulation of leukocyte mediated cytotoxicity|
|response to gamma radiation|
|natural killer cell activation|
|negative regulation of sequestering of calcium ion|
|positive regulation of dephosphorylation|
|positive regulation of alpha-beta T cell activation|
|regulation of B cell proliferation|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of immunoglobulin production|
|negative regulation of response to cytokine stimulus|
|regulation of stem cell proliferation|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of cell killing|
|calcium ion transmembrane import into cytosol|
|positive regulation of cytokine biosynthetic process|
|positive regulation of phagocytosis|
|regulation of interleukin-8 production|
|regulation of T cell mediated immunity|
|calcium ion transport into cytosol|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of T cell differentiation|
|lymphocyte proliferation|
|stem cell development|
|localization within membrane|
|positive regulation of tumor necrosis factor production|
|mononuclear cell proliferation|
|hematopoietic progenitor cell differentiation|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|cytosolic calcium ion transport|
|regulation of protein tyrosine kinase activity|
|regulation of alpha-beta T cell activation|
|plasma membrane organization|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|regulation of phagocytosis|
|positive regulation of production of molecular mediator of immune response|
|secretory granule membrane|
|leukocyte proliferation|
|protein tyrosine phosphatase activity|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|peptidyl-tyrosine dephosphorylation|
|regulation of DNA recombination|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of cytokine biosynthetic process|
|B cell differentiation|
|regulation of phosphoprotein phosphatase activity|
|negative regulation of immune effector process|
|regulation of sequestering of calcium ion|
|B cell receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|negative regulation of inflammatory response|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of protein dephosphorylation|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|calcium-mediated signaling|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|response to ionizing radiation|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|B cell activation|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|regulation of T cell proliferation|
|immunoglobulin production|
|stem cell differentiation|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|heparin binding|
|positive regulation of apoptotic signaling pathway|
|negative regulation of leukocyte activation|
|T cell receptor signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of phosphatase activity|
|production of molecular mediator of immune response|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|positive regulation of DNA metabolic process|
|negative regulation of cell activation|
|calcium ion transmembrane transport|
|bone development|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|protein dephosphorylation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|membrane raft|
|T cell activation|
|lymphocyte differentiation|
|negative regulation of kinase activity|
|calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|cellular response to extracellular stimulus|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|cell cycle phase transition|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|dephosphorylation|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|leukocyte differentiation|
|cellular response to external stimulus|
|signaling receptor binding|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|focal adhesion|
|positive regulation of cell activation|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|response to radiation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|protein kinase binding|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|skeletal system development|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|cellular metal ion homeostasis|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|cell surface|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|cation transport|
|regulation of cell migration|
|membrane organization|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15336
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRC Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>