PTPRF [The Human Chemical-Genetic Interaction Map Project]

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======= PTPRF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRF
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5792|5792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10586|P10586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
|fn3|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chondroitin sulfate proteoglycan binding|
|transmembrane receptor protein tyrosine phosphatase signaling pathway|
|negative regulation of receptor binding|
|transmembrane receptor protein tyrosine phosphatase activity|
|synaptic membrane adhesion|
|regulation of receptor binding|
|regulation of axon regeneration|
|regulation of neuron projection regeneration|
|neuron projection regeneration|
|cell adhesion molecule binding|
|protein tyrosine phosphatase activity|
|negative regulation of protein binding|
|peptidyl-tyrosine dephosphorylation|
|regeneration|
|regulation of response to wounding|
|heparin binding|
|negative regulation of binding|
|protein dephosphorylation|
|regulation of protein binding|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|protein-containing complex binding|
|synapse organization|
|dephosphorylation|
|neuron projection|
|neuronal cell body|
|regulation of binding|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|neuron development|
|regulation of neurogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|neuron differentiation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|locomotion|
|integral component of plasma membrane|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular response to stress|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.82|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.8|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.9|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRF Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>