PTRHD1 [The Human Chemical-Genetic Interaction Map Project]

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======= PTRHD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTRHD1
  * **<color #00a2e8>Official Name</color>**: peptidyl-tRNA hydrolase domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=391356|391356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6GMV3|Q6GMV3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTRHD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTRHD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617342|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme peptidyl-tRNA hydrolase. Peptidyl-tRNA hydrolases perform the essential function of recycling peptidyl-tRNAs. Mutations in this gene are associated with autosomal-recessive intellectual disability and parkinsonism. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminoacyl-tRNA hydrolase activity|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.51|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.83|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps34|MRPS34]]|0.485|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.482|
|[[:human genes:s:selrc1|SELRC1]]|0.461|
|[[:human genes:m:mrps18a|MRPS18A]]|0.431|
|[[:human genes:i:iba57|IBA57]]|0.418|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:r:rpusd4|RPUSD4]]|0.416|
|[[:human genes:c:c17orf89|C17orf89]]|0.413|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.411|
|[[:human genes:d:dhx30|DHX30]]|0.411|
|[[:human genes:n:nars2|NARS2]]|0.408|
|[[:human genes:e:ears2|EARS2]]|0.407|
|[[:human genes:m:mrps5|MRPS5]]|0.407|
|[[:human genes:c:coq3|COQ3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTRHD1 Expression in NALM6 Cells: 3.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>