PUS3 [The Human Chemical-Genetic Interaction Map Project]

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======= PUS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PUS3
  * **<color #00a2e8>Official Name</color>**: pseudouridine synthase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83480|83480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZE2|Q9BZE2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PUS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PUS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PseudoU synth 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA pseudouridine synthase activity|
|mRNA pseudouridine synthesis|
|tRNA pseudouridine synthesis|
|pseudouridine synthase activity|
|pseudouridine synthesis|
|mRNA modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.88|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.73|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.7|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.75|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.82|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.82|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.85|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.87|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.88|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.9|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.91|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.92|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.01|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.02|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.03|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.06|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.09|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.13|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.18|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.5|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.51|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.75|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppcdc|PPCDC]]|0.456|
|[[:human genes:l:lsm10|LSM10]]|0.425|
|[[:human genes:a:adat2|ADAT2]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1920
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PUS3 Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>