PYGO2 [The Human Chemical-Genetic Interaction Map Project]

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======= PYGO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PYGO2
  * **<color #00a2e8>Official Name</color>**: pygopus family PHD finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90780|90780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRQ0|Q9BRQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PYGO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PYGO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in signal transduction through the Wnt pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone acetyltransferase regulator activity|
|beta-catenin-TCF complex|
|positive regulation of chromatin binding|
|regulation of mammary gland epithelial cell proliferation|
|spermatid nucleus differentiation|
|regulation of chromatin binding|
|regulation of histone H3-K4 methylation|
|beta-catenin-TCF complex assembly|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|regulation of histone methylation|
|regulation of protein acetylation|
|lens development in camera-type eye|
|post-embryonic development|
|canonical Wnt signaling pathway|
|roof of mouth development|
|mammary gland development|
|histone binding|
|nucleus organization|
|regulation of histone modification|
|spermatid development|
|spermatid differentiation|
|positive regulation of binding|
|regulation of chromatin organization|
|germ cell development|
|kidney development|
|renal system development|
|camera-type eye development|
|urogenital system development|
|regulation of epithelial cell proliferation|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|regulation of binding|
|in utero embryonic development|
|developmental growth|
|growth|
|chromatin binding|
|gland development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|embryo development|
|central nervous system development|
|multi-organism reproductive process|
|cell-cell signaling|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|cell development|
|positive regulation of molecular function|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.25|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.97|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.91|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.9|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.76|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.84|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.88|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.16|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lef1|LEF1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PYGO2 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>