QARS [The Human Chemical-Genetic Interaction Map Project]

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======= QARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: QARS1
  * **<color #00a2e8>Official Name</color>**: glutaminyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5859|5859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47897|P47897]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=QARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20QARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603727|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA synt 1c R2|
|tRNA-synt 1c C|
|tRNA-synt 1c|
|tRNA synt 1c R1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutaminyl-tRNA aminoacylation|
|glutamine-tRNA ligase activity|
|aminoacyl-tRNA synthetase multienzyme complex|
|protein kinase inhibitor activity|
|negative regulation of stress-activated MAPK cascade|
|tRNA aminoacylation for protein translation|
|negative regulation of stress-activated protein kinase signaling cascade|
|tRNA aminoacylation|
|amino acid activation|
|negative regulation of MAPK cascade|
|tRNA metabolic process|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|peptide biosynthetic process|
|negative regulation of phosphorylation|
|protein kinase binding|
|ncRNA metabolic process|
|negative regulation of intracellular signal transduction|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of transferase activity|
|central nervous system development|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.64|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.85|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.69|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.39|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.35|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.19|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.05|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.96|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.94|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.92|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.84|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.81|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.8|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.78|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.74|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.71|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.72|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.75|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.77|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.91|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.18|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.27|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.41|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg13|ALG13]]|0.464|
|[[:human genes:g:gmppb|GMPPB]]|0.455|
|[[:human genes:r:rnmt|RNMT]]|0.448|
|[[:human genes:l:lsm11|LSM11]]|0.434|
|[[:human genes:d:dpagt1|DPAGT1]]|0.433|
|[[:human genes:g:gfpt1|GFPT1]]|0.429|
|[[:human genes:a:alg2|ALG2]]|0.417|
|[[:human genes:e:eprs|EPRS]]|0.403|
|[[:human genes:d:ddx55|DDX55]]|0.401|
|[[:human genes:c:c21orf59|C21orf59]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='QARS Expression in NALM6 Cells: 7.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>