RAB10 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB10
  * **<color #00a2e8>Official Name</color>**: RAB10, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10890|10890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61026|P61026]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612672|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. {ECO:0000250, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
|Gtr1 RagA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of neuroblast polarity|
|establishment of protein localization to endoplasmic reticulum membrane|
|establishment or maintenance of neuroblast polarity|
|asymmetric neuroblast division|
|protein localization to basolateral plasma membrane|
|insulin-responsive compartment|
|asymmetric stem cell division|
|endoplasmic reticulum tubular network organization|
|endoplasmic reticulum tubular network|
|neuroblast division|
|neuronal stem cell division|
|asymmetric cell division|
|myosin V binding|
|cadherin binding involved in cell-cell adhesion|
|polarized epithelial cell differentiation|
|exocyst|
|somatic stem cell division|
|exocytic vesicle|
|neuroblast proliferation|
|stem cell division|
|Golgi to plasma membrane protein transport|
|vesicle docking involved in exocytosis|
|morphogenesis of a polarized epithelium|
|establishment of protein localization to plasma membrane|
|stem cell proliferation|
|endoplasmic reticulum organization|
|Golgi to plasma membrane transport|
|vesicle docking|
|exocytic process|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|neural precursor cell proliferation|
|GDP binding|
|recycling endosome membrane|
|vesicle-mediated transport to the plasma membrane|
|secretory granule membrane|
|post-Golgi vesicle-mediated transport|
|cell-cell adherens junction|
|establishment of protein localization to endoplasmic reticulum|
|recycling endosome|
|establishment of cell polarity|
|synaptic vesicle|
|protein localization to endoplasmic reticulum|
|cytoplasmic vesicle membrane|
|protein secretion|
|establishment of protein localization to extracellular region|
|cellular response to insulin stimulus|
|protein localization to extracellular region|
|organelle localization by membrane tethering|
|trans-Golgi network|
|peptide secretion|
|membrane docking|
|protein localization to plasma membrane|
|establishment or maintenance of cell polarity|
|cilium|
|antigen processing and presentation|
|regulation of exocytosis|
|response to insulin|
|protein localization to cell periphery|
|endosomal transport|
|cell fate commitment|
|Ras protein signal transduction|
|establishment of protein localization to membrane|
|cellular response to peptide hormone stimulus|
|endosome|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|GTPase activity|
|axonogenesis|
|Golgi vesicle transport|
|GTP binding|
|response to peptide hormone|
|axon development|
|focal adhesion|
|endomembrane system organization|
|establishment of protein localization to organelle|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|response to peptide|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|organelle localization|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|neuron projection development|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|cell morphogenesis|
|protein localization to organelle|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|response to hormone|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-3.3|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.85|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.83|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.93|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.99|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.05|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.19|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.22|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.39|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.44|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.56|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.63|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rabif|RABIF]]|0.554|
|[[:human genes:d:dennd4a|DENND4A]]|0.5|
|[[:human genes:t:taz|TAZ]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 76/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|2/28|
|bone|1/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|0/21|
|liver|0/20|
|lung|10/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|9/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB10 Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>