RAB11FIP3 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB11FIP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB11FIP3
  * **<color #00a2e8>Official Name</color>**: RAB11 family interacting protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9727|9727]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75154|O75154]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB11FIP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB11FIP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608738|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RBD-FIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of adiponectin secretion|
|regulation of adiponectin secretion|
|ADP-ribosylation factor binding|
|dynein light intermediate chain binding|
|endocytic recycling|
|regulation of endocrine process|
|protein localization to cilium|
|cleavage furrow|
|endocytic vesicle|
|intercellular bridge|
|negative regulation of hormone secretion|
|recycling endosome membrane|
|regulation of cytokinesis|
|recycling endosome|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|Rab GTPase binding|
|midbody|
|microtubule organizing center|
|regulation of cell division|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|endosomal transport|
|negative regulation of secretion|
|regulation of hormone secretion|
|endosome|
|regulation of protein secretion|
|negative regulation of transport|
|centrosome|
|cell division|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of system process|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|calcium ion binding|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of secretion|
|protein homodimerization activity|
|regulation of protein localization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|intracellular transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.03|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3965
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB11FIP3 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>