RAB11FIP5 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB11FIP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB11FIP5
  * **<color #00a2e8>Official Name</color>**: RAB11 family interacting protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26056|26056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXF6|Q9BXF6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB11FIP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB11FIP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605536|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|RBD-FIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of adiponectin secretion|
|regulation of adiponectin secretion|
|insulin secretion involved in cellular response to glucose stimulus|
|cellular response to acidic pH|
|cellular response to pH|
|response to acidic pH|
|gamma-tubulin binding|
|regulation of protein localization to cell surface|
|insulin secretion|
|response to pH|
|transport vesicle membrane|
|regulation of endocrine process|
|peptide hormone secretion|
|negative regulation of hormone secretion|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|hormone secretion|
|cellular response to carbohydrate stimulus|
|hormone transport|
|recycling endosome membrane|
|secretory granule|
|cellular glucose homeostasis|
|recycling endosome|
|negative regulation of protein secretion|
|response to glucose|
|negative regulation of peptide secretion|
|response to hexose|
|response to monosaccharide|
|Rab GTPase binding|
|early endosome membrane|
|microtubule organizing center|
|protein secretion|
|establishment of protein localization to extracellular region|
|mitochondrial outer membrane|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|negative regulation of establishment of protein localization|
|carbohydrate homeostasis|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|early endosome|
|regulation of hormone secretion|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of system process|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|cellular homeostasis|
|regulation of cellular localization|
|Golgi apparatus|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.71|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB11FIP5 Expression in NALM6 Cells: 1.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>