RAB27B [The Human Chemical-Genetic Interaction Map Project]

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======= RAB27B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB27B
  * **<color #00a2e8>Official Name</color>**: RAB27B, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5874|5874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00194|O00194]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB27B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB27B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603869|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in targeting uroplakins to urothelial apical membranes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet dense granule membrane|
|protein localization to presynapse|
|anterograde axonal protein transport|
|zymogen granule membrane|
|multivesicular body membrane|
|axo-dendritic protein transport|
|anchored component of synaptic vesicle membrane|
|trans-Golgi network transport vesicle|
|myosin V binding|
|melanosome transport|
|establishment of melanosome localization|
|pigment granule transport|
|establishment of pigment granule localization|
|melanosome localization|
|pigment granule localization|
|multivesicular body sorting pathway|
|Golgi stack|
|anterograde axonal transport|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|cellular pigmentation|
|synaptic vesicle recycling|
|axonal transport|
|axon cytoplasm|
|protein localization to synapse|
|axo-dendritic transport|
|protein transport along microtubule|
|microtubule-based protein transport|
|Rab protein signal transduction|
|GDP binding|
|secretory granule|
|positive regulation of exocytosis|
|pigmentation|
|melanosome|
|synaptic vesicle cycle|
|platelet degranulation|
|vesicle-mediated transport in synapse|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|regulation of exocytosis|
|protein domain specific binding|
|Ras protein signal transduction|
|microtubule-based movement|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|GTPase activity|
|establishment of organelle localization|
|GTP binding|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|microtubule-based process|
|import into cell|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB27B Expression in NALM6 Cells: -1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>