RAB44 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB44
  * **<color #00a2e8>Official Name</color>**: RAB44, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=401258|401258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6P3|Q7Z6P3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Gtr1 RagA|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|azurophil granule membrane|
|Rab protein signal transduction|
|specific granule membrane|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|calcium ion binding|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.06|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.86|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.98|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB44 Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>