RAB8B [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RAB8B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB8B
  * **<color #00a2e8>Official Name</color>**: RAB8B, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51762|51762]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92930|Q92930]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB8B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB8B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi vesicle fusion to target membrane|
|cell tip|
|positive regulation of corticotropin secretion|
|regulation of corticotropin secretion|
|protein import into peroxisome membrane|
|TPR domain binding|
|trans-Golgi network transport vesicle|
|peroxisomal membrane transport|
|vesicle docking involved in exocytosis|
|regulation of endocrine process|
|peroxisomal membrane|
|phagocytic vesicle|
|vesicle docking|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|exocytic process|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|vesicle fusion|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|GDP binding|
|organelle membrane fusion|
|peroxisome organization|
|adherens junction organization|
|recycling endosome membrane|
|organelle fusion|
|positive regulation of peptide hormone secretion|
|synaptic vesicle|
|positive regulation of hormone secretion|
|membrane fusion|
|protein import|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein targeting to membrane|
|cellular response to insulin stimulus|
|protein localization to extracellular region|
|organelle localization by membrane tethering|
|peptide secretion|
|membrane docking|
|protein localization to plasma membrane|
|regulation of peptide hormone secretion|
|cell junction organization|
|antigen processing and presentation|
|regulation of exocytosis|
|response to insulin|
|protein localization to cell periphery|
|Ras protein signal transduction|
|establishment of protein localization to membrane|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|endosome|
|nuclear body|
|positive regulation of peptide secretion|
|vesicle organization|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|GTPase activity|
|signaling receptor binding|
|cilium assembly|
|protein targeting|
|cilium organization|
|Golgi vesicle transport|
|positive regulation of cell projection organization|
|GTP binding|
|response to peptide hormone|
|positive regulation of secretion by cell|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|response to peptide|
|protein localization to membrane|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|organelle localization|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of secretion by cell|
|organelle assembly|
|exocytosis|
|regulation of secretion|
|membrane organization|
|response to hormone|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.02|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.73|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.75|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8569
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB8B Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>