RAB9A [The Human Chemical-Genetic Interaction Map Project]

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======= RAB9A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB9A
  * **<color #00a2e8>Official Name</color>**: RAB9A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9367|9367]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51151|P51151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB9A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB9A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300284|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:Q9R0M6}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation by host of symbiont molecular function|
|modulation by host of symbiont molecular function|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|negative regulation of molecular function in other organism|
|modulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism|
|phagocytic vesicle|
|modification by host of symbiont morphology or physiology|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|GDP binding|
|interaction with symbiont|
|positive regulation of exocytosis|
|transport vesicle|
|trans-Golgi network membrane|
|retrograde transport, endosome to Golgi|
|melanosome|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|late endosome|
|cytosolic transport|
|modification of morphology or physiology of other organism|
|regulation of exocytosis|
|endosomal transport|
|Ras protein signal transduction|
|lysosome|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|regulation of vesicle-mediated transport|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|identical protein binding|
|negative regulation of molecular function|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.79|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.77|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19022
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB9A Expression in NALM6 Cells: 3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>