RALA [The Human Chemical-Genetic Interaction Map Project]

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======= RALA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RALA
  * **<color #00a2e8>Official Name</color>**: RAS like proto-oncogene A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5898|5898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11233|P11233]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RALA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RALA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage- independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Edg-2 lysophosphatidic acid receptor binding|
|membrane raft localization|
|myosin binding|
|Flemming body|
|positive regulation of filopodium assembly|
|regulation of filopodium assembly|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|cleavage furrow|
|endocytic vesicle|
|actin cytoskeleton reorganization|
|GDP binding|
|ATPase binding|
|localization within membrane|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|positive regulation of plasma membrane bounded cell projection assembly|
|neural tube formation|
|embryonic epithelial tube formation|
|epithelial tube formation|
|cytoplasmic vesicle membrane|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of exocytosis|
|Ras protein signal transduction|
|ubiquitin protein ligase binding|
|epithelial tube morphogenesis|
|small GTPase mediated signal transduction|
|GTPase activity|
|positive regulation of cell projection organization|
|GTP binding|
|focal adhesion|
|morphogenesis of an epithelium|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|tube development|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|secretion|
|positive regulation of cellular component organization|
|locomotion|
|cell cycle|
|intracellular signal transduction|
|tissue development|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.78|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.9|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.03|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.26|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.36|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16919
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RALA Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>