RAMP3 [The Human Chemical-Genetic Interaction Map Project]

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======= RAMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAMP3
  * **<color #00a2e8>Official Name</color>**: receptor activity modifying protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10268|10268]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60896|O60896]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605155|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RAMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcium ion import across plasma membrane|
|amylin receptor complex 3|
|cross-receptor inhibition within G protein-coupled receptor heterodimer|
|adrenomedullin receptor activity|
|adrenomedullin receptor complex|
|regulation of calcium ion import across plasma membrane|
|amylin receptor activity|
|adrenomedullin receptor signaling pathway|
|amylin receptor signaling pathway|
|calcitonin family receptor signaling pathway|
|G protein-coupled receptor signaling pathway involved in heart process|
|positive regulation of protein kinase A signaling|
|positive regulation of receptor recycling|
|positive regulation of calcium ion import|
|regulation of protein kinase A signaling|
|regulation of receptor recycling|
|coreceptor activity|
|cellular response to estradiol stimulus|
|regulation of calcium ion import|
|response to amyloid-beta|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of protein localization to plasma membrane|
|negative regulation of signaling receptor activity|
|receptor internalization|
|positive regulation of protein localization to cell periphery|
|positive regulation of calcium ion transmembrane transport|
|cell|
|amyloid-beta binding|
|regulation of protein localization to plasma membrane|
|regulation of calcium ion transport into cytosol|
|heart process|
|positive regulation of peptidyl-serine phosphorylation|
|receptor metabolic process|
|regulation of protein localization to cell periphery|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|response to estradiol|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of cation transmembrane transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of calcium ion transmembrane transport|
|cAMP-mediated signaling|
|positive regulation of ion transmembrane transport|
|positive regulation of protein kinase B signaling|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|calcium ion transport|
|lysosome|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|angiogenesis|
|positive regulation of cellular protein localization|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of metal ion transport|
|circulatory system process|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|blood vessel development|
|divalent inorganic cation homeostasis|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|endocytosis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|cellular response to hormone stimulus|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|tube morphogenesis|
|import into cell|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|cation transport|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.83|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.83|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.91|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.06|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4717
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAMP3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>