RAP2B [The Human Chemical-Genetic Interaction Map Project]

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======= RAP2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAP2B
  * **<color #00a2e8>Official Name</color>**: RAP2B, member of RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5912|5912]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61225|P61225]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAP2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAP2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rap protein signal transduction|
|establishment of endothelial intestinal barrier|
|microvillus assembly|
|microvillus organization|
|cell-cell contact zone|
|positive regulation of protein autophosphorylation|
|establishment of endothelial barrier|
|platelet aggregation|
|regulation of protein autophosphorylation|
|endothelial cell development|
|homotypic cell-cell adhesion|
|tertiary granule membrane|
|GDP binding|
|endothelial cell differentiation|
|recycling endosome membrane|
|regulation of protein tyrosine kinase activity|
|specific granule membrane|
|endothelium development|
|bicellular tight junction|
|platelet activation|
|epithelial cell development|
|membrane raft|
|protein domain specific binding|
|Ras protein signal transduction|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|negative regulation of cell motility|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of cellular component movement|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|GTPase activity|
|GTP binding|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to wounding|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|epithelial cell differentiation|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.72|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13340
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAP2B Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>