RAPGEF3 [The Human Chemical-Genetic Interaction Map Project]

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======= RAPGEF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPGEF3
  * **<color #00a2e8>Official Name</color>**: Rap guanine nucleotide exchange factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10411|10411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95398|O95398]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPGEF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPGEF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606057|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF|
|DEP|
|cNMP binding|
|RasGEF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of syncytium formation by plasma membrane fusion|
|Rap guanyl-nucleotide exchange factor activity|
|Rap protein signal transduction|
|regulation of histone H3-K9 acetylation|
|positive regulation of protein export from nucleus|
|cAMP binding|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|establishment of endothelial barrier|
|regulation of actin cytoskeleton reorganization|
|regulation of protein export from nucleus|
|positive regulation of protein acetylation|
|endothelial cell development|
|positive regulation of stress fiber assembly|
|cortical actin cytoskeleton|
|cellular response to cAMP|
|regulation of histone acetylation|
|positive regulation of actin filament bundle assembly|
|regulation of peptidyl-lysine acetylation|
|positive regulation of nucleocytoplasmic transport|
|microvillus|
|regulation of protein acetylation|
|filopodium|
|endomembrane system|
|regulation of stress fiber assembly|
|endothelial cell differentiation|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|endothelium development|
|response to cAMP|
|guanyl-nucleotide exchange factor activity|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|response to organophosphorus|
|regulation of peptidyl-serine phosphorylation|
|regulation of histone modification|
|cAMP-mediated signaling|
|response to purine-containing compound|
|positive regulation of intracellular protein transport|
|positive regulation of angiogenesis|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|lamellipodium|
|positive regulation of vasculature development|
|regulation of chromatin organization|
|epithelial cell development|
|positive regulation of supramolecular fiber organization|
|positive regulation of intracellular transport|
|regulation of peptide hormone secretion|
|positive regulation of cytoskeleton organization|
|regulation of intracellular protein transport|
|protein domain specific binding|
|Ras protein signal transduction|
|regulation of actin filament organization|
|regulation of hormone secretion|
|regulation of angiogenesis|
|angiogenesis|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|regulation of chromosome organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|regulation of actin filament-based process|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of GTPase activity|
|blood vessel development|
|regulation of peptide secretion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|tube morphogenesis|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|response to organic cyclic compound|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.23|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.19|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.92|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPGEF3 Expression in NALM6 Cells: 1.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>