RAPH1 [The Human Chemical-Genetic Interaction Map Project]

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======= RAPH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPH1
  * **<color #00a2e8>Official Name</color>**: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65059|65059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q70E73|Q70E73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|RA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|axon extension|
|neuron projection extension|
|filopodium|
|developmental cell growth|
|cell growth|
|developmental growth involved in morphogenesis|
|lamellipodium|
|nuclear body|
|cytoskeleton|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.54|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.05|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.03|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.97|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.8|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.77|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.77|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.74|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.74|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17653
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPH1 Expression in NALM6 Cells: 0.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>