RARS2 [The Human Chemical-Genetic Interaction Map Project]

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======= RARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RARS2
  * **<color #00a2e8>Official Name</color>**: arginyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57038|57038]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T160|Q5T160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DALR 1|
|tRNA-synt 1d|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arginine-tRNA ligase activity|
|arginyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.21|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.05|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.9|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.74|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.74|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.77|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.79|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.84|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.89|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.91|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.91|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.93|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.94|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.95|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.02|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.04|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.31|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.34|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.45|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.56|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.742|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.722|
|[[:human genes:q:qrsl1|QRSL1]]|0.685|
|[[:human genes:y:yars2|YARS2]]|0.674|
|[[:human genes:m:mrps6|MRPS6]]|0.669|
|[[:human genes:m:mrps21|MRPS21]]|0.669|
|[[:human genes:g:gfm1|GFM1]]|0.658|
|[[:human genes:d:dap3|DAP3]]|0.653|
|[[:human genes:m:mrps14|MRPS14]]|0.652|
|[[:human genes:s:selrc1|SELRC1]]|0.65|
|[[:human genes:p:pars2|PARS2]]|0.649|
|[[:human genes:m:mrps16|MRPS16]]|0.648|
|[[:human genes:m:mrpl21|MRPL21]]|0.646|
|[[:human genes:d:dars2|DARS2]]|0.641|
|[[:human genes:h:hars2|HARS2]]|0.64|
|[[:human genes:m:mars2|MARS2]]|0.635|
|[[:human genes:m:mrpl23|MRPL23]]|0.629|
|[[:human genes:m:mrps26|MRPS26]]|0.628|
|[[:human genes:t:tars2|TARS2]]|0.625|
|[[:human genes:e:ears2|EARS2]]|0.618|
|[[:human genes:m:mrps34|MRPS34]]|0.618|
|[[:human genes:l:lars2|LARS2]]|0.615|
|[[:human genes:r:rpusd4|RPUSD4]]|0.614|
|[[:human genes:a:aars2|AARS2]]|0.608|
|[[:human genes:f:fastkd5|FASTKD5]]|0.607|
|[[:human genes:c:cox16|COX16]]|0.606|
|[[:human genes:v:vars2|VARS2]]|0.603|
|[[:human genes:p:pet112|PET112]]|0.602|
|[[:human genes:s:sco2|SCO2]]|0.599|
|[[:human genes:m:mrp63|MRP63]]|0.599|
|[[:human genes:c:coa3|COA3]]|0.593|
|[[:human genes:m:mrps5|MRPS5]]|0.592|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.59|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.589|
|[[:human genes:w:wbscr16|WBSCR16]]|0.586|
|[[:human genes:c:c10orf2|C10orf2]]|0.586|
|[[:human genes:m:mrps25|MRPS25]]|0.579|
|[[:human genes:r:rbfa|RBFA]]|0.578|
|[[:human genes:m:mrps9|MRPS9]]|0.564|
|[[:human genes:t:tefm|TEFM]]|0.564|
|[[:human genes:g:gatc|GATC]]|0.563|
|[[:human genes:c:cox7b|COX7B]]|0.561|
|[[:human genes:m:mrpl53|MRPL53]]|0.559|
|[[:human genes:m:mrpl47|MRPL47]]|0.558|
|[[:human genes:r:rpusd3|RPUSD3]]|0.557|
|[[:human genes:m:mrps22|MRPS22]]|0.553|
|[[:human genes:b:bcs1l|BCS1L]]|0.552|
|[[:human genes:p:pnpt1|PNPT1]]|0.551|
|[[:human genes:m:mrpl20|MRPL20]]|0.549|
|[[:human genes:c:cox11|COX11]]|0.549|
|[[:human genes:t:tfb1m|TFB1M]]|0.549|
|[[:human genes:m:mtg2|MTG2]]|0.545|
|[[:human genes:t:trub2|TRUB2]]|0.543|
|[[:human genes:c:cox15|COX15]]|0.543|
|[[:human genes:g:gfm2|GFM2]]|0.542|
|[[:human genes:m:mrps18a|MRPS18A]]|0.542|
|[[:human genes:m:mrpl45|MRPL45]]|0.541|
|[[:human genes:c:c12orf65|C12orf65]]|0.541|
|[[:human genes:p:polg2|POLG2]]|0.54|
|[[:human genes:p:pet117|PET117]]|0.539|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.538|
|[[:human genes:m:mtg1|MTG1]]|0.536|
|[[:human genes:m:mrpl3|MRPL3]]|0.535|
|[[:human genes:p:polg|POLG]]|0.534|
|[[:human genes:f:ftsj2|FTSJ2]]|0.534|
|[[:human genes:m:mettl17|METTL17]]|0.532|
|[[:human genes:m:mrps12|MRPS12]]|0.531|
|[[:human genes:m:mrpl43|MRPL43]]|0.531|
|[[:human genes:t:tufm|TUFM]]|0.527|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.525|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.523|
|[[:human genes:m:mrpl18|MRPL18]]|0.522|
|[[:human genes:n:ndufb11|NDUFB11]]|0.519|
|[[:human genes:m:mrps10|MRPS10]]|0.519|
|[[:human genes:f:fars2|FARS2]]|0.517|
|[[:human genes:w:wars2|WARS2]]|0.517|
|[[:human genes:c:cars2|CARS2]]|0.516|
|[[:human genes:c:coa6|COA6]]|0.516|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.515|
|[[:human genes:p:pdss1|PDSS1]]|0.515|
|[[:human genes:m:mrpl42|MRPL42]]|0.515|
|[[:human genes:m:mrps35|MRPS35]]|0.514|
|[[:human genes:m:mrpl12|MRPL12]]|0.514|
|[[:human genes:n:ndufa3|NDUFA3]]|0.512|
|[[:human genes:c:cox20|COX20]]|0.509|
|[[:human genes:d:dnlz|DNLZ]]|0.506|
|[[:human genes:a:atp5sl|ATP5SL]]|0.505|
|[[:human genes:t:tomm20|TOMM20]]|0.503|
|[[:human genes:m:mrps2|MRPS2]]|0.502|
|[[:human genes:c:cox17|COX17]]|0.501|
|[[:human genes:m:mrpl15|MRPL15]]|0.496|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.493|
|[[:human genes:s:slc25a26|SLC25A26]]|0.49|
|[[:human genes:m:mrps24|MRPS24]]|0.489|
|[[:human genes:m:mterfd1|MTERFD1]]|0.488|
|[[:human genes:a:atp5b|ATP5B]]|0.487|
|[[:human genes:m:mrpl33|MRPL33]]|0.486|
|[[:human genes:n:ndufc2|NDUFC2]]|0.486|
|[[:human genes:p:polrmt|POLRMT]]|0.485|
|[[:human genes:p:pgm3|PGM3]]|0.485|
|[[:human genes:m:mrpl51|MRPL51]]|0.485|
|[[:human genes:m:mrpl17|MRPL17]]|0.484|
|[[:human genes:m:mrpl4|MRPL4]]|0.484|
|[[:human genes:m:mrpl55|MRPL55]]|0.483|
|[[:human genes:t:tfam|TFAM]]|0.483|
|[[:human genes:m:mtif2|MTIF2]]|0.482|
|[[:human genes:m:mrps23|MRPS23]]|0.482|
|[[:human genes:m:mrpl11|MRPL11]]|0.479|
|[[:human genes:s:sars2|SARS2]]|0.479|
|[[:human genes:d:ddx28|DDX28]]|0.475|
|[[:human genes:n:ndufa1|NDUFA1]]|0.473|
|[[:human genes:a:atp5c1|ATP5C1]]|0.473|
|[[:human genes:a:aifm1|AIFM1]]|0.472|
|[[:human genes:m:mtpap|MTPAP]]|0.47|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.47|
|[[:human genes:a:atp5a1|ATP5A1]]|0.47|
|[[:human genes:m:mrps27|MRPS27]]|0.47|
|[[:human genes:l:lsm10|LSM10]]|0.468|
|[[:human genes:a:atp5d|ATP5D]]|0.467|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.465|
|[[:human genes:m:mrps11|MRPS11]]|0.463|
|[[:human genes:e:elac2|ELAC2]]|0.462|
|[[:human genes:n:ndufs2|NDUFS2]]|0.461|
|[[:human genes:p:ptcd3|PTCD3]]|0.461|
|[[:human genes:n:nsun4|NSUN4]]|0.461|
|[[:human genes:m:malsu1|MALSU1]]|0.46|
|[[:human genes:n:ndufa2|NDUFA2]]|0.459|
|[[:human genes:m:mrpl28|MRPL28]]|0.457|
|[[:human genes:c:cox6b1|COX6B1]]|0.456|
|[[:human genes:e:eral1|ERAL1]]|0.456|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.454|
|[[:human genes:c:clpp|CLPP]]|0.453|
|[[:human genes:c:cox19|COX19]]|0.453|
|[[:human genes:m:mrps7|MRPS7]]|0.453|
|[[:human genes:d:dhrsx|DHRSX]]|0.448|
|[[:human genes:m:mrps33|MRPS33]]|0.447|
|[[:human genes:m:mipep|MIPEP]]|0.446|
|[[:human genes:n:ndufb9|NDUFB9]]|0.445|
|[[:human genes:c:chchd1|CHCHD1]]|0.445|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.445|
|[[:human genes:a:atp5h|ATP5H]]|0.445|
|[[:human genes:m:mrpl13|MRPL13]]|0.445|
|[[:human genes:c:c1qbp|C1QBP]]|0.443|
|[[:human genes:t:tmem242|TMEM242]]|0.442|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.435|
|[[:human genes:g:grsf1|GRSF1]]|0.434|
|[[:human genes:p:ppa2|PPA2]]|0.434|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.433|
|[[:human genes:n:nubpl|NUBPL]]|0.433|
|[[:human genes:t:triap1|TRIAP1]]|0.431|
|[[:human genes:m:mrpl44|MRPL44]]|0.431|
|[[:human genes:m:mcat|MCAT]]|0.431|
|[[:human genes:f:fastkd1|FASTKD1]]|0.43|
|[[:human genes:a:acad9|ACAD9]]|0.428|
|[[:human genes:t:tomm22|TOMM22]]|0.428|
|[[:human genes:m:mterfd2|MTERFD2]]|0.427|
|[[:human genes:c:cox6c|COX6C]]|0.427|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.427|
|[[:human genes:s:slc25a3|SLC25A3]]|0.426|
|[[:human genes:m:mrpl41|MRPL41]]|0.426|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.426|
|[[:human genes:t:trmt10c|TRMT10C]]|0.425|
|[[:human genes:f:fh|FH]]|0.424|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:s:ssbp1|SSBP1]]|0.421|
|[[:human genes:m:mrps18b|MRPS18B]]|0.421|
|[[:human genes:m:mrpl38|MRPL38]]|0.419|
|[[:human genes:c:coq7|COQ7]]|0.417|
|[[:human genes:u:uqcrq|UQCRQ]]|0.417|
|[[:human genes:c:coq2|COQ2]]|0.417|
|[[:human genes:s:slc25a52|SLC25A52]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.416|
|[[:human genes:c:cox5a|COX5A]]|0.416|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.415|
|[[:human genes:a:aurkaip1|AURKAIP1]]|0.415|
|[[:human genes:m:mrpl37|MRPL37]]|0.414|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.411|
|[[:human genes:i:iba57|IBA57]]|0.411|
|[[:human genes:m:mrpl22|MRPL22]]|0.409|
|[[:human genes:c:c17orf89|C17orf89]]|0.408|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.406|
|[[:human genes:n:ndufv1|NDUFV1]]|0.405|
|[[:human genes:l:lrpprc|LRPPRC]]|0.404|
|[[:human genes:m:mrpl49|MRPL49]]|0.404|
|[[:human genes:h:hccs|HCCS]]|0.404|
|[[:human genes:m:mrpl39|MRPL39]]|0.402|
|[[:human genes:p:pmvk|PMVK]]|0.402|
|[[:human genes:n:ndufb3|NDUFB3]]|0.402|
|[[:human genes:n:ndufb6|NDUFB6]]|0.402|
|[[:human genes:m:mrpl35|MRPL35]]|0.401|
|[[:human genes:m:mrpl32|MRPL32]]|0.401|
|[[:human genes:u:uqcc2|UQCC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 216/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|3/28|
|bone|8/26|
|breast|10/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|4/21|
|liver|6/20|
|lung|25/75|
|lymphocyte|6/16|
|ovary|1/26|
|pancreas|6/24|
|peripheral nervous system|2/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 761
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RARS2 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>