RASA1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RASA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASA1
  * **<color #00a2e8>Official Name</color>**: RAS p21 protein activator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5921|5921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20936|P20936]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. {ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:8360177}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|SH2|
|SH3 1|
|C2|
|RasGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|potassium channel inhibitor activity|
|GTPase binding|
|negative regulation of cell-matrix adhesion|
|phosphotyrosine residue binding|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|negative regulation of cell-substrate adhesion|
|vasculogenesis|
|mitotic cytokinesis|
|ephrin receptor signaling pathway|
|ruffle|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|regulation of cell-matrix adhesion|
|negative regulation of neuron apoptotic process|
|regulation of cell shape|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of cell-substrate adhesion|
|regulation of protein polymerization|
|regulation of Ras protein signal transduction|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|GTPase activator activity|
|regulation of neuron death|
|GTPase activity|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|MAPK cascade|
|regulation of cellular component size|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|regulation of protein complex assembly|
|regulation of GTPase activity|
|blood vessel development|
|regulation of cell morphogenesis|
|cell division|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cardiovascular system development|
|regulation of cytoskeleton organization|
|mitotic cell cycle process|
|tube morphogenesis|
|regulation of cell adhesion|
|mitotic cell cycle|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|negative regulation of cell death|
|cell cycle process|
|regulation of anatomical structure morphogenesis|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.05|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.91|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.86|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.79|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.71|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.7|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASA1 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>