RASGRF2 [The Human Chemical-Genetic Interaction Map Project]

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======= RASGRF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASGRF2
  * **<color #00a2e8>Official Name</color>**: Ras protein specific guanine nucleotide releasing factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5924|5924]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14827|O14827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASGRF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASGRF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|RasGEF|
|RhoGEF|
|RasGEF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ras guanyl-nucleotide exchange factor activity|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of Rho protein signal transduction|
|calmodulin binding|
|regulation of Ras protein signal transduction|
|response to endoplasmic reticulum stress|
|small GTPase mediated signal transduction|
|regulation of small GTPase mediated signal transduction|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|endoplasmic reticulum membrane|
|protein phosphorylation|
|endoplasmic reticulum|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASGRF2 Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>