RASIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RASIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASIP1
  * **<color #00a2e8>Official Name</color>**: Ras interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54922|54922]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5U651|Q5U651]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609623|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RA|
|DIL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Rho-dependent protein serine/threonine kinase activity|
|regulation of Rho-dependent protein serine/threonine kinase activity|
|positive regulation of integrin activation|
|negative regulation of membrane permeability|
|regulation of integrin activation|
|negative regulation of Rho protein signal transduction|
|GTPase binding|
|Golgi stack|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|vasculogenesis|
|regulation of membrane permeability|
|negative regulation of autophagy|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein serine/threonine kinase activity|
|regulation of Rho protein signal transduction|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cell-cell junction|
|negative regulation of protein kinase activity|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|positive regulation of protein complex assembly|
|negative regulation of cellular catabolic process|
|negative regulation of transferase activity|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|angiogenesis|
|regulation of autophagy|
|regulation of small GTPase mediated signal transduction|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|morphogenesis of an epithelium|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|regulation of GTPase activity|
|blood vessel development|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|negative regulation of protein modification process|
|protein-containing complex|
|tube morphogenesis|
|perinuclear region of cytoplasm|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.7|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.85|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.86|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.91|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.04|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.3|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.499|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASIP1 Expression in NALM6 Cells: -0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>