RBBP4 [The Human Chemical-Genetic Interaction Map Project]

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======= RBBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBBP4
  * **<color #00a2e8>Official Name</color>**: RB binding protein 4, chromatin remodeling factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5928|5928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q09028|Q09028]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF1C H4-bd|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CAF-1 complex|
|NURF complex|
|DNA replication-dependent nucleosome assembly|
|DNA replication-dependent nucleosome organization|
|Sin3 complex|
|NuRD complex|
|ESC/E(Z) complex|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|negative regulation of G0 to G1 transition|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|regulation of G0 to G1 transition|
|nucleosomal DNA binding|
|DNA-dependent ATPase activity|
|histone exchange|
|ATP-dependent chromatin remodeling|
|negative regulation of gene expression, epigenetic|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|histone deacetylase binding|
|nucleosome assembly|
|histone binding|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|regulation of signal transduction by p53 class mediator|
|protein-DNA complex assembly|
|DNA replication|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|DNA conformation change|
|negative regulation of cell cycle process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of cell cycle|
|protein-containing complex|
|negative regulation of cell population proliferation|
|chromatin organization|
|regulation of cell cycle process|
|cellular protein-containing complex assembly|
|chromosome organization|
|regulation of cell cycle|
|cell cycle|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.26|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.07|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.99|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.85|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.473|
|[[:human genes:t:ten1|TEN1]]|0.449|
|[[:human genes:g:gemin8|GEMIN8]]|0.433|
|[[:human genes:k:kif18a|KIF18A]]|0.416|
|[[:human genes:a:atp2b1|ATP2B1]]|0.408|
|[[:human genes:r:rpia|RPIA]]|0.401|
|[[:human genes:c:c14orf80|C14orf80]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 287/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|10/28|
|bone|15/25|
|breast|15/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|5/15|
|kidney|11/21|
|liver|10/20|
|lung|23/75|
|lymphocyte|4/14|
|ovary|4/26|
|pancreas|11/24|
|peripheral nervous system|14/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|0/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1404
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBBP4 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>