RBM10 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM10
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8241|8241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98175|P98175]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:28431233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch 2|
|zf-RanBP|
|RRM 1|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of smooth muscle cell apoptotic process|
|3-UTR-mediated mRNA stabilization|
|negative regulation of mRNA splicing, via spliceosome|
|regulation of smooth muscle cell apoptotic process|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|positive regulation of muscle cell apoptotic process|
|miRNA binding|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of muscle cell apoptotic process|
|negative regulation of mRNA metabolic process|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|positive regulation of cell death|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|regulation of catabolic process|
|identical protein binding|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.94|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.9|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.84|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.73|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.91|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.98|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.11|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.12|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.41|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|3.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 65/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/26|
|bone|4/26|
|breast|5/30|
|central nervous system|3/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|2/18|
|liver|0/19|
|lung|9/72|
|lymphocyte|2/16|
|ovary|4/25|
|pancreas|1/22|
|peripheral nervous system|3/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|3/20|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM10 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>