RBM26 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM26
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64062|64062]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T8P6|Q5T8P6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620081|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of RNA export from nucleus|
|positive regulation of nucleobase-containing compound transport|
|regulation of RNA export from nucleus|
|regulation of nucleobase-containing compound transport|
|positive regulation of nucleocytoplasmic transport|
|negative regulation of phosphatase activity|
|regulation of nucleocytoplasmic transport|
|negative regulation of dephosphorylation|
|mRNA binding|
|regulation of phosphatase activity|
|positive regulation of intracellular transport|
|regulation of dephosphorylation|
|regulation of intracellular transport|
|negative regulation of hydrolase activity|
|mRNA processing|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|mRNA metabolic process|
|negative regulation of catalytic activity|
|RNA processing|
|regulation of cellular localization|
|positive regulation of transport|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|RNA binding|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-4.36|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.15|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-3.05|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.86|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.62|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.52|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.51|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.49|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.34|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.29|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.22|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.17|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.16|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.15|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.13|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.05|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.01|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.85|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.84|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.84|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.78|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.78|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.77|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.75|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.71|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.74|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.75|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.8|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.84|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.87|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.93|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.94|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.97|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.02|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.06|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.13|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.13|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.16|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.21|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.22|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.27|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.29|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.33|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.35|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.35|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.36|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.56|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.68|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.73|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.01|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|3.07|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.1|
|[[:results:exp275|Citral 75μM R06 exp275]]|3.22|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|3.24|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.32|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|3.84|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|4.14|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|4.29|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|4.35|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|4.69|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.75|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|5.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:ythdf2|YTHDF2]]|0.525|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.491|
|[[:human genes:h:hexim1|HEXIM1]]|0.481|
|[[:human genes:b:brd1|BRD1]]|0.48|
|[[:human genes:p:pcgf1|PCGF1]]|0.463|
|[[:human genes:a:arid4b|ARID4B]]|0.461|
|[[:human genes:r:rreb1|RREB1]]|0.453|
|[[:human genes:b:brms1|BRMS1]]|0.447|
|[[:human genes:s:sap130|SAP130]]|0.443|
|[[:human genes:c:cxorf56|CXorf56]]|0.429|
|[[:human genes:c:c7orf26|C7orf26]]|0.427|
|[[:human genes:a:anp32a|ANP32A]]|0.417|
|[[:human genes:p:pou2f1|POU2F1]]|0.417|
|[[:human genes:i:itpk1|ITPK1]]|0.417|
|[[:human genes:p:ppil1|PPIL1]]|0.413|
|[[:human genes:c:cbll1|CBLL1]]|0.413|
|[[:human genes:z:zbtb7a|ZBTB7A]]|0.411|
|[[:human genes:i:ing1|ING1]]|0.408|
|[[:human genes:m:mettl14|METTL14]]|0.403|
|[[:human genes:d:dph3|DPH3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM26 Expression in NALM6 Cells: 7.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>