RBM48 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM48 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM48
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 48
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84060|84060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5RL73|Q5RL73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM48&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM48|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.47|
|[[:human genes:r:rpl35|RPL35]]|0.441|
|[[:human genes:a:arcn1|ARCN1]]|0.427|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.415|
|[[:human genes:e:exosc6|EXOSC6]]|0.412|
|[[:human genes:c:col2a1|COL2A1]]|0.412|
|[[:human genes:a:atp6v1e1|ATP6V1E1]]|0.406|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 448/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|14/28|
|bone|21/26|
|breast|23/33|
|central nervous system|39/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|13/21|
|liver|12/20|
|lung|35/75|
|lymphocyte|10/16|
|ovary|13/26|
|pancreas|8/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1744
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM48 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>