RBM6 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM6
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10180|10180]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78332|P78332]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606886|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically binds poly(G) RNA homopolymers in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA processing|
|RNA binding|
|DNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.56|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.36|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.7|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.71|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.73|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.73|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.01|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.19|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.22|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.43|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.76|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arid2|ARID2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9817
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM6 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>