RBMX [The Human Chemical-Genetic Interaction Map Project]

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======= RBMX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBMX
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27316|27316]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P38159|P38159]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBMX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBMX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300199|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RBM1CTR|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|supraspliceosomal complex|
|negative regulation of mRNA splicing, via spliceosome|
|positive regulation of mRNA splicing, via spliceosome|
|membrane protein ectodomain proteolysis|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|nuclear euchromatin|
|positive regulation of mRNA processing|
|mRNA splice site selection|
|positive regulation of RNA splicing|
|membrane protein proteolysis|
|single-stranded RNA binding|
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|osteoblast differentiation|
|regulation of RNA splicing|
|regulation of mRNA processing|
|ribonucleoprotein complex|
|mRNA binding|
|cellular response to interleukin-1|
|response to interleukin-1|
|ribonucleoprotein complex assembly|
|protein domain specific binding|
|ribonucleoprotein complex subunit organization|
|ossification|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|protein homooligomerization|
|chromatin binding|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|protein complex oligomerization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular response to cytokine stimulus|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.22|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.98|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|1/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBMX Expression in NALM6 Cells: 9.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>