RBP4 [The Human Chemical-Genetic Interaction Map Project]

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======= RBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBP4
  * **<color #00a2e8>Official Name</color>**: retinol binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5950|5950]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02753|P02753]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). {ECO:0000269|PubMed:22665496, ECO:0000305, ECO:0000305|PubMed:5541771}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
|Lipocalin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|terpenoid transport|
|retinol transport|
|retinol transmembrane transporter activity|
|isoprenoid transport|
|female genitalia morphogenesis|
|urinary bladder development|
|embryonic retina morphogenesis in camera-type eye|
|retinal binding|
|vagina development|
|positive regulation of immunoglobulin secretion|
|negative regulation of cardiac muscle cell proliferation|
|heart trabecula formation|
|retinol binding|
|genitalia morphogenesis|
|female genitalia development|
|regulation of immunoglobulin secretion|
|maintenance of gastrointestinal epithelium|
|uterus development|
|trabecula formation|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|epithelial structure maintenance|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|heart trabecula morphogenesis|
|regulation of cardiac muscle cell proliferation|
|retinol metabolic process|
|positive regulation of immunoglobulin production|
|gluconeogenesis|
|trabecula morphogenesis|
|hexose biosynthetic process|
|genitalia development|
|negative regulation of striated muscle tissue development|
|retina morphogenesis in camera-type eye|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|monosaccharide biosynthetic process|
|regulation of cardiac muscle tissue growth|
|regulation of heart growth|
|regulation of immunoglobulin production|
|positive regulation of insulin secretion|
|digestive system process|
|primary alcohol metabolic process|
|regulation of cardiac muscle tissue development|
|regulation of organ growth|
|positive regulation of peptide hormone secretion|
|positive regulation of production of molecular mediator of immune response|
|retinoid metabolic process|
|negative regulation of developmental growth|
|female sex differentiation|
|response to retinoic acid|
|diterpenoid metabolic process|
|digestion|
|camera-type eye morphogenesis|
|glucose metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|carbohydrate biosynthetic process|
|embryonic skeletal system development|
|response to ethanol|
|cardiac chamber morphogenesis|
|positive regulation of hormone secretion|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|organic hydroxy compound transport|
|isoprenoid metabolic process|
|retina development in camera-type eye|
|regulation of production of molecular mediator of immune response|
|eye morphogenesis|
|hexose metabolic process|
|cardiac muscle tissue development|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|tissue homeostasis|
|respiratory system development|
|monosaccharide metabolic process|
|hormone metabolic process|
|regulation of peptide hormone secretion|
|positive regulation of immune effector process|
|visual perception|
|sensory perception of light stimulus|
|response to alcohol|
|negative regulation of growth|
|heart morphogenesis|
|sensory organ morphogenesis|
|sex differentiation|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|renal system development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|muscle tissue development|
|lipid transport|
|response to antibiotic|
|camera-type eye development|
|alcohol metabolic process|
|urogenital system development|
|lipid localization|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|anatomical structure homeostasis|
|response to acid chemical|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of secretion by cell|
|reproductive structure development|
|positive regulation of protein transport|
|reproductive system development|
|embryonic organ development|
|positive regulation of secretion|
|organic hydroxy compound metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|carbohydrate metabolic process|
|protein heterodimerization activity|
|skeletal system development|
|regulation of peptide secretion|
|response to toxic substance|
|heart development|
|regulation of hormone levels|
|sensory organ development|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|chemical homeostasis|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|nervous system process|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|small molecule metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.87|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.71|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.525|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBP4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>