RBPJ [The Human Chemical-Genetic Interaction Map Project]

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======= RBPJ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBPJ
  * **<color #00a2e8>Official Name</color>**: recombination signal binding protein for immunoglobulin kappa J region
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3516|3516]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06330|Q06330]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBPJ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBPJ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147183|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:21991380, ECO:0000269|PubMed:23303788}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LAG1-DNAbind|
|Beta-trefoil|
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of canonical Wnt signaling pathway involved in heart development|
|positive regulation of ephrin receptor signaling pathway|
|positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|
|blood vessel lumenization|
|arterial endothelial cell fate commitment|
|regulation of ephrin receptor signaling pathway|
|regulation of canonical Wnt signaling pathway involved in heart development|
|regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|
|MAML1-RBP-Jkappa- ICN1 complex|
|endothelial cell fate specification|
|blood vessel endothelial cell fate commitment|
|epidermal cell fate specification|
|blood vessel endothelial cell fate specification|
|auditory receptor cell fate commitment|
|inner ear receptor cell fate commitment|
|Clara cell differentiation|
|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|endocardium morphogenesis|
|regulation of Wnt signaling pathway involved in heart development|
|positive regulation of cell proliferation involved in heart morphogenesis|
|arterial endothelial cell differentiation|
|interleukin-4 secretion|
|hair follicle maturation|
|interleukin-4 production|
|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|atrioventricular canal development|
|endothelial cell fate commitment|
|sebaceous gland development|
|dorsal aorta morphogenesis|
|blood vessel endothelial cell differentiation|
|heart field specification|
|dorsal aorta development|
|positive regulation of cell fate commitment|
|secondary heart field specification|
|cardiac muscle cell myoblast differentiation|
|Notch signaling involved in heart development|
|morphogenesis of an endothelium|
|endothelial tube morphogenesis|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|endocardium development|
|regulation of timing of cell differentiation|
|heart formation|
|cardioblast differentiation|
|epithelial cell fate commitment|
|cardiac left ventricle morphogenesis|
|regulation of development, heterochronic|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|specification of animal organ identity|
|ventricular trabecula myocardium morphogenesis|
|regulation of cell proliferation involved in heart morphogenesis|
|myeloid dendritic cell differentiation|
|positive regulation of transcription of Notch receptor target|
|positive regulation of cardiac muscle cell differentiation|
|labyrinthine layer blood vessel development|
|lung epithelial cell differentiation|
|endocardial cushion formation|
|lung cell differentiation|
|pulmonary valve development|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|myeloid dendritic cell activation|
|cell surface receptor signaling pathway involved in heart development|
|inflammatory response to antigenic stimulus|
|positive regulation of cardiac muscle cell proliferation|
|inner ear auditory receptor cell differentiation|
|aorta morphogenesis|
|cardiac epithelial to mesenchymal transition|
|positive regulation of cardiocyte differentiation|
|regulation of cell fate commitment|
|placenta blood vessel development|
|lung epithelium development|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|aortic valve development|
|blood vessel remodeling|
|positive regulation of BMP signaling pathway|
|dendritic cell differentiation|
|heart trabecula morphogenesis|
|positive regulation of ERBB signaling pathway|
|positive regulation of cardiac muscle tissue growth|
|animal organ formation|
|hair cell differentiation|
|endocardial cushion morphogenesis|
|myoblast differentiation|
|RNA polymerase II repressing transcription factor binding|
|regulation of cardiac muscle cell differentiation|
|semi-lunar valve development|
|positive regulation of heart growth|
|repressing transcription factor binding|
|regulation of cardiac muscle cell proliferation|
|regulation of heart morphogenesis|
|ventricular septum morphogenesis|
|pituitary gland development|
|endocardial cushion development|
|positive regulation of cardiac muscle tissue development|
|neuroepithelial cell differentiation|
|trabecula morphogenesis|
|labyrinthine layer development|
|negative regulation of cold-induced thermogenesis|
|cytokine secretion|
|ventricular cardiac muscle tissue morphogenesis|
|positive regulation of organ growth|
|mesenchyme morphogenesis|
|regulation of cardiocyte differentiation|
|aorta development|
|inner ear receptor cell differentiation|
|positive regulation of Notch signaling pathway|
|ventricular cardiac muscle tissue development|
|transcriptional repressor complex|
|mechanoreceptor differentiation|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|heart valve development|
|artery morphogenesis|
|regulation of heart growth|
|neuron fate commitment|
|somatic stem cell population maintenance|
|somitogenesis|
|cardiac muscle tissue morphogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|epithelial to mesenchymal transition|
|positive regulation of muscle tissue development|
|hair follicle development|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|negative regulation of ossification|
|skin epidermis development|
|cardiac ventricle morphogenesis|
|hair cycle process|
|molting cycle process|
|diencephalon development|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|positive regulation of animal organ morphogenesis|
|endothelial cell differentiation|
|somite development|
|artery development|
|positive regulation of muscle cell differentiation|
|muscle organ morphogenesis|
|embryonic placenta development|
|cell fate specification|
|regulation of BMP signaling pathway|
|regulation of ERBB signaling pathway|
|hair cycle|
|molting cycle|
|regulation of organ growth|
|segmentation|
|endothelium development|
|columnar/cuboidal epithelial cell differentiation|
|tissue remodeling|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein N-terminus binding|
|B cell differentiation|
|cardiac septum development|
|myeloid leukocyte differentiation|
|cardiocyte differentiation|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|endocrine system development|
|regulation of DNA-templated transcription in response to stress|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|stem cell population maintenance|
|anatomical structure maturation|
|regulation of muscle organ development|
|maintenance of cell number|
|regulation of cold-induced thermogenesis|
|positive regulation of canonical Wnt signaling pathway|
|cytokine production|
|placenta development|
|regulation of muscle cell differentiation|
|B cell activation|
|mesenchymal cell differentiation|
|protein secretion|
|stem cell differentiation|
|establishment of protein localization to extracellular region|
|cardiac muscle tissue development|
|protein localization to extracellular region|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|respiratory tube development|
|peptide secretion|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of Wnt signaling pathway|
|cellular response to hypoxia|
|regulation of ossification|
|inner ear development|
|respiratory system development|
|cellular response to decreased oxygen levels|
|transcription factor complex|
|cellular response to oxygen levels|
|DNA-templated transcription, initiation|
|anterior/posterior pattern specification|
|myeloid cell differentiation|
|ear development|
|mesenchyme development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|lymphocyte differentiation|
|developmental maturation|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|regulation of cellular response to growth factor stimulus|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|epidermal cell differentiation|
|angiogenesis|
|regulation of developmental growth|
|defense response to bacterium|
|leukocyte differentiation|
|regionalization|
|transcription factor binding|
|response to hypoxia|
|humoral immune response|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|response to oxygen levels|
|skin development|
|lymphocyte activation|
|forebrain development|
|chromatin binding|
|blood vessel morphogenesis|
|gland development|
|epidermis development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|transcription by RNA polymerase II|
|blood vessel development|
|inflammatory response|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|hemopoiesis|
|tissue morphogenesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|response to bacterium|
|negative regulation of cell differentiation|
|brain development|
|head development|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|secretion by cell|
|neuron differentiation|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|secretion|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.33|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.29|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.29|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.06|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.02|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.99|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.97|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.93|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.88|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.83|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.81|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.79|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.79|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.78|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.75|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.74|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.72|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.72|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBPJ Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>