RCAN1 [The Human Chemical-Genetic Interaction Map Project]

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======= RCAN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCAN1
  * **<color #00a2e8>Official Name</color>**: regulator of calcineurin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1827|1827]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53805|P53805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCAN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCAN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calcipressin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein serine/threonine phosphatase regulator activity|
|calcineurin-NFAT signaling cascade|
|negative regulation of calcineurin-mediated signaling|
|negative regulation of calcineurin-NFAT signaling cascade|
|calcineurin-mediated signaling|
|inositol phosphate-mediated signaling|
|negative regulation of calcium-mediated signaling|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcium-mediated signaling|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|calcium-mediated signaling|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|negative regulation of intracellular signal transduction|
|DNA-binding transcription factor activity|
|central nervous system development|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|DNA binding|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.74|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14878
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCAN1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>